Identification of difurocumenonol, a new antimicrobial compound from mango ginger (Curcuma amada Roxb.) rhizome
Aim: The aim of the present work was to purify and characterize potential natural antibacterial compound from mango ginger (Curcuma amada Roxb.) rhizome. Methods and Results: The mango ginger rhizome powder was sequentially extracted and screened for antibacterial activity by agar well diffusion m...
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| Veröffentlicht in: | Journal of applied microbiology 2007-06, Vol.102 (6), p.1594-1602 |
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| creator | Policegoudra, R.S. Divakar, S. Aradhya, S.M. |
| description | Aim: The aim of the present work was to purify and characterize potential natural antibacterial compound from mango ginger (Curcuma amada Roxb.) rhizome.
Methods and Results: The mango ginger rhizome powder was sequentially extracted and screened for antibacterial activity by agar well diffusion method and broth dilution method. Nonpolar extracts of mango ginger showed high antibacterial activity against gram‐positive bacteria with low minimum inhibitory concentration (60–180 ppm). Among five extracts of mango ginger, the chloroform extract demonstrated highest antibacterial activity. Antibacterial activity‐guided fractionation of the chloroform extract by repeated silica gel column chromatography yielded pure compound. The purified antibacterial compound was analysed by UV, IR, LC‐MS and 2D‐HMQCT NMR spectra and was identified as a difurocumenonol, a novel compound not reported previously.
Conclusions: Mango ginger extracts and isolated difurocumenonol demonstrated high antibacterial activity against gram‐negative and gram‐positive bacteria.
Significance and Impact of the Study: A novel and natural antibacterial compound as well as mango ginger extracts can be used as food preservative to control the growth of food‐borne pathogens and as a source of mango flavour. |
| doi_str_mv | 10.1111/j.1365-2672.2006.03186.x |
| format | Article |
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Methods and Results: The mango ginger rhizome powder was sequentially extracted and screened for antibacterial activity by agar well diffusion method and broth dilution method. Nonpolar extracts of mango ginger showed high antibacterial activity against gram‐positive bacteria with low minimum inhibitory concentration (60–180 ppm). Among five extracts of mango ginger, the chloroform extract demonstrated highest antibacterial activity. Antibacterial activity‐guided fractionation of the chloroform extract by repeated silica gel column chromatography yielded pure compound. The purified antibacterial compound was analysed by UV, IR, LC‐MS and 2D‐HMQCT NMR spectra and was identified as a difurocumenonol, a novel compound not reported previously.
Conclusions: Mango ginger extracts and isolated difurocumenonol demonstrated high antibacterial activity against gram‐negative and gram‐positive bacteria.
Significance and Impact of the Study: A novel and natural antibacterial compound as well as mango ginger extracts can be used as food preservative to control the growth of food‐borne pathogens and as a source of mango flavour.</description><identifier>ISSN: 1364-5072</identifier><identifier>EISSN: 1365-2672</identifier><identifier>DOI: 10.1111/j.1365-2672.2006.03186.x</identifier><identifier>PMID: 17578425</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anti-Bacterial Agents - isolation & purification ; antibacterial activity ; bactericidal ; Benzofurans - chemistry ; Benzofurans - isolation & purification ; Biological and medical sciences ; Chloroform ; Curcuma ; Curcuma - chemistry ; Curcuma amada ; Cyclodecanes - chemistry ; Cyclodecanes - isolation & purification ; difurocumenonol ; Fundamental and applied biological sciences. Psychology ; Gram-Negative Bacteria - drug effects ; Gram-Positive Bacteria - drug effects ; Mangifera indica ; mango ginger ; MIC ; Microbial Sensitivity Tests - methods ; Microbiology ; Nuclear Magnetic Resonance, Biomolecular - methods ; rhizome ; Rhizome - chemistry ; Spectrometry, Mass, Electrospray Ionization - methods ; Spectrophotometry, Ultraviolet - methods ; Spectrum Analysis - methods</subject><ispartof>Journal of applied microbiology, 2007-06, Vol.102 (6), p.1594-1602</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3976-7f5da40534e5e1ffd6e3b66213f5b4aca48005ab8ae757e823b1256ad06439ed3</citedby><cites>FETCH-LOGICAL-c3976-7f5da40534e5e1ffd6e3b66213f5b4aca48005ab8ae757e823b1256ad06439ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2672.2006.03186.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2672.2006.03186.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18767166$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17578425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Policegoudra, R.S.</creatorcontrib><creatorcontrib>Divakar, S.</creatorcontrib><creatorcontrib>Aradhya, S.M.</creatorcontrib><title>Identification of difurocumenonol, a new antimicrobial compound from mango ginger (Curcuma amada Roxb.) rhizome</title><title>Journal of applied microbiology</title><addtitle>J Appl Microbiol</addtitle><description>Aim: The aim of the present work was to purify and characterize potential natural antibacterial compound from mango ginger (Curcuma amada Roxb.) rhizome.
Methods and Results: The mango ginger rhizome powder was sequentially extracted and screened for antibacterial activity by agar well diffusion method and broth dilution method. Nonpolar extracts of mango ginger showed high antibacterial activity against gram‐positive bacteria with low minimum inhibitory concentration (60–180 ppm). Among five extracts of mango ginger, the chloroform extract demonstrated highest antibacterial activity. Antibacterial activity‐guided fractionation of the chloroform extract by repeated silica gel column chromatography yielded pure compound. The purified antibacterial compound was analysed by UV, IR, LC‐MS and 2D‐HMQCT NMR spectra and was identified as a difurocumenonol, a novel compound not reported previously.
Conclusions: Mango ginger extracts and isolated difurocumenonol demonstrated high antibacterial activity against gram‐negative and gram‐positive bacteria.
Significance and Impact of the Study: A novel and natural antibacterial compound as well as mango ginger extracts can be used as food preservative to control the growth of food‐borne pathogens and as a source of mango flavour.</description><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>antibacterial activity</subject><subject>bactericidal</subject><subject>Benzofurans - chemistry</subject><subject>Benzofurans - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Chloroform</subject><subject>Curcuma</subject><subject>Curcuma - chemistry</subject><subject>Curcuma amada</subject><subject>Cyclodecanes - chemistry</subject><subject>Cyclodecanes - isolation & purification</subject><subject>difurocumenonol</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>Mangifera indica</subject><subject>mango ginger</subject><subject>MIC</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Microbiology</subject><subject>Nuclear Magnetic Resonance, Biomolecular - methods</subject><subject>rhizome</subject><subject>Rhizome - chemistry</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Spectrophotometry, Ultraviolet - methods</subject><subject>Spectrum Analysis - methods</subject><issn>1364-5072</issn><issn>1365-2672</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFvFCEUx4nR2Lr1KxguGk2cKQwDzB56aDa2tqkxMXombxhY2Qywwk669dOX6W7sVS7vJe_3B94PIUxJTcs539SUCV41QjZ1Q4ioCaOdqPcv0Om_wcunvq04kc0JepPzhhDKCBev0QmVXHZtw09RvBlM2DnrNOxcDDhaPDg7pagnb0IMcfyMAQdzj6Fg3ukUewcj1tFv4xQGbFP02ENYR7x2YW0S_riaUkkDBg8D4B9x39efcPrt_kZvztArC2M2b491gX5dffm5-lrdfb--WV3eVZotpaik5QO0hLPWcEOtHYRhvRANZZb3LWhoO0I49B2YsorpGtbThgsYiGjZ0gxsgT4c7t2m-Gcyeae8y9qMIwQTp6zoUi6ZLLkF6g5g2SznZKzaJuchPShK1CxbbdTsVM1O1SxbPclW-xJ9d3xj6r0ZnoNHuwV4fwQgaxhtgqBdfuY6KSQVonAXB-7ejebhvz-gbi-_zR17BPkIm4c</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Policegoudra, R.S.</creator><creator>Divakar, S.</creator><creator>Aradhya, S.M.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>200706</creationdate><title>Identification of difurocumenonol, a new antimicrobial compound from mango ginger (Curcuma amada Roxb.) rhizome</title><author>Policegoudra, R.S. ; Divakar, S. ; Aradhya, S.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3976-7f5da40534e5e1ffd6e3b66213f5b4aca48005ab8ae757e823b1256ad06439ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>antibacterial activity</topic><topic>bactericidal</topic><topic>Benzofurans - chemistry</topic><topic>Benzofurans - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Chloroform</topic><topic>Curcuma</topic><topic>Curcuma - chemistry</topic><topic>Curcuma amada</topic><topic>Cyclodecanes - chemistry</topic><topic>Cyclodecanes - isolation & purification</topic><topic>difurocumenonol</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>Mangifera indica</topic><topic>mango ginger</topic><topic>MIC</topic><topic>Microbial Sensitivity Tests - methods</topic><topic>Microbiology</topic><topic>Nuclear Magnetic Resonance, Biomolecular - methods</topic><topic>rhizome</topic><topic>Rhizome - chemistry</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Spectrophotometry, Ultraviolet - methods</topic><topic>Spectrum Analysis - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Policegoudra, R.S.</creatorcontrib><creatorcontrib>Divakar, S.</creatorcontrib><creatorcontrib>Aradhya, S.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Policegoudra, R.S.</au><au>Divakar, S.</au><au>Aradhya, S.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of difurocumenonol, a new antimicrobial compound from mango ginger (Curcuma amada Roxb.) rhizome</atitle><jtitle>Journal of applied microbiology</jtitle><addtitle>J Appl Microbiol</addtitle><date>2007-06</date><risdate>2007</risdate><volume>102</volume><issue>6</issue><spage>1594</spage><epage>1602</epage><pages>1594-1602</pages><issn>1364-5072</issn><eissn>1365-2672</eissn><abstract>Aim: The aim of the present work was to purify and characterize potential natural antibacterial compound from mango ginger (Curcuma amada Roxb.) rhizome.
Methods and Results: The mango ginger rhizome powder was sequentially extracted and screened for antibacterial activity by agar well diffusion method and broth dilution method. Nonpolar extracts of mango ginger showed high antibacterial activity against gram‐positive bacteria with low minimum inhibitory concentration (60–180 ppm). Among five extracts of mango ginger, the chloroform extract demonstrated highest antibacterial activity. Antibacterial activity‐guided fractionation of the chloroform extract by repeated silica gel column chromatography yielded pure compound. The purified antibacterial compound was analysed by UV, IR, LC‐MS and 2D‐HMQCT NMR spectra and was identified as a difurocumenonol, a novel compound not reported previously.
Conclusions: Mango ginger extracts and isolated difurocumenonol demonstrated high antibacterial activity against gram‐negative and gram‐positive bacteria.
Significance and Impact of the Study: A novel and natural antibacterial compound as well as mango ginger extracts can be used as food preservative to control the growth of food‐borne pathogens and as a source of mango flavour.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17578425</pmid><doi>10.1111/j.1365-2672.2006.03186.x</doi><tpages>9</tpages></addata></record> |
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| subjects | Anti-Bacterial Agents - isolation & purification antibacterial activity bactericidal Benzofurans - chemistry Benzofurans - isolation & purification Biological and medical sciences Chloroform Curcuma Curcuma - chemistry Curcuma amada Cyclodecanes - chemistry Cyclodecanes - isolation & purification difurocumenonol Fundamental and applied biological sciences. Psychology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Mangifera indica mango ginger MIC Microbial Sensitivity Tests - methods Microbiology Nuclear Magnetic Resonance, Biomolecular - methods rhizome Rhizome - chemistry Spectrometry, Mass, Electrospray Ionization - methods Spectrophotometry, Ultraviolet - methods Spectrum Analysis - methods |
| title | Identification of difurocumenonol, a new antimicrobial compound from mango ginger (Curcuma amada Roxb.) rhizome |
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