Cystic fibrosis in the mouse by targeted insertional mutagenesis

Cystic flbrosis is a fatal genetic disorder which afflicts 50,000 people worldwide. A viable animal model would be invaluable for investigating and combating this disease. The mouse cystic flbrosis transmembrane conductance regulator gene was disrupted in embryonal stem cells using an insertional ge...

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Veröffentlicht in:	Nature (London) 1992-09, Vol.359 (6392), p.211-215
Hauptverfasser:	Dorin, Julia R, Dickinson, Paul, Alton, Eric W. F. W, Smith, Stephen N, Geddes, Duncan M, Stevenson, Barbara J, Kimber, Wendy L, Fleming, Stewart, Clarke, Alan R, Hooper, Martin L, Anderson, Louise, Beddington, Rosa S. P, Porteous, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biological and medical sciences Biological Transport Chimera Chlorine - pharmacokinetics Chromosome Mapping Cystic fibrosis Cystic Fibrosis - genetics Cystic Fibrosis - pathology Cystic Fibrosis Transmembrane Conductance Regulator Disease Models, Animal Female Gastroenterology. Liver. Pancreas. Abdomen Genes, Regulator - physiology Genotype Humanities and Social Sciences Ion transport Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical research Medical sciences Membrane Potentials Membrane Proteins - genetics Mice Mice, Inbred Strains multidisciplinary Mutagenesis, Insertional Mutation Offspring Other diseases. Semiology Rodents Science Science (multidisciplinary) Stem cells
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