A Transgenic Dual-Luciferase Reporter Mouse for Longitudinal and Functional Monitoring of T Cells In Vivo

Adoptive T-cell therapy (ATT) efficacy is limited when targeting large solid tumors. The evaluation of ATT outcomes using accessory treatment would greatly benefit from an monitoring tool, allowing the detection of functional parameters of transferred T cells. Here, we generated transgenic biolumine...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer immunology research 2018-01, Vol.6 (1), p.110-120
Hauptverfasser:	Szyska, Martin, Herda, Stefanie, Althoff, Stefanie, Heimann, Andreas, Russ, Josefine, D'Abundo, Daniele, Dang, Tra My, Durieux, Isabell, Dörken, Bernd, Blankenstein, Thomas, Na, Il-Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Transplantation - adverse effects Bone Marrow Transplantation - methods Cell Tracking - methods Disease Models, Animal Female Gene Expression Gene Order Genes, Reporter Genetic Vectors - genetics Graft vs Host Disease - etiology Luciferases - genetics Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Lymphocytes, Tumor-Infiltrating - pathology Male Mice Mice, Knockout Mice, Transgenic Recurrence T-Lymphocytes - immunology T-Lymphocytes - metabolism Transduction, Genetic Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!