Kainate-induced seizures, oxidative stress and neuronal loss in aging rats

Abstract Aging is a significant risk factor for developing epilepsy. The mechanisms underlying age-related increase in seizure susceptibility and resultant injury remain unknown. Oxidative stress is an important mechanism that contributes to diverse age-related disorders. Whether age-related increas...

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Veröffentlicht in:	Neuroscience 2007-07, Vol.147 (4), p.1114-1118
Hauptverfasser:	Liang, L.P, Beaudoin, M.E, Fritz, M.J, Fulton, R, Patel, M
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - physiology Animals Behavior, Animal - drug effects Biological and medical sciences Cell Death - drug effects Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Dose-Response Relationship, Drug epilepsy Fundamental and applied biological sciences. Psychology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy hippocampus Kainic Acid Male Medical sciences Nervous system (semeiology, syndromes) Neurology neuronal death Neurons - drug effects Neurons - metabolism oxidative damage Oxidative Stress - drug effects Oxidative Stress - physiology Rats Rats, Sprague-Dawley Seizures - chemically induced Seizures - metabolism Seizures - pathology Severity of Illness Index Time Factors Vertebrates: nervous system and sense organs
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