Origin, evolution, and migration of drug resistance genes
Current views on the mechanisms responsible for the emergence of multiple drug resistance in clinical bacterial isolates are considered. Hypotheses on the origin of resistance genes derived from determinants of actinomycetes, antibiotic-producing strains, and chromosomal genes of bacteria involved i...
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| Veröffentlicht in: | Russian journal of genetics 2006-11, Vol.42 (11), p.1257-1271 |
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| container_end_page | 1271 |
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| container_issue | 11 |
| container_start_page | 1257 |
| container_title | Russian journal of genetics |
| container_volume | 42 |
| creator | Mindlin, S. Z. Petrova, M. A. Bass, I. A. Gorlenko, Zh. M. |
| description | Current views on the mechanisms responsible for the emergence of multiple drug resistance in clinical bacterial isolates are considered. Hypotheses on the origin of resistance genes derived from determinants of actinomycetes, antibiotic-producing strains, and chromosomal genes of bacteria involved in cellular metabolism are reviewed. The mechanisms underlying the diffusion of resistance determinants by means of bacterial mobile elements (plasmids, transposons, and integrons) are discussed. Examples of the horizontal transfer of resistance determinants between Gram-positive and Gram-negative bacteria are presented. |
| doi_str_mv | 10.1134/S1022795406110081 |
| format | Article |
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| ispartof | Russian journal of genetics, 2006-11, Vol.42 (11), p.1257-1271 |
| issn | 1022-7954 1608-3369 |
| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| title | Origin, evolution, and migration of drug resistance genes |
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