Gravity-Related Immunological Changes in Human Whole Blood Cultured Under Simulated Microgravity Using an In Vitro Cytokine Release Assay

Although immune dysfunction by space conditions has been reported postflight, as well as during ground-based experiments, the cause(s) and nature of the immunological changes are not completely understood. Microgravity has been suggested as one of the factors responsible for the observed immune dysr...

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Veröffentlicht in:	Journal of interferon & cytokine research 2017-12, Vol.37 (12), p.531-540
Hauptverfasser:	Van Walleghem, Merel, Tabury, Kevin, Fernandez-Gonzalo, Rodrigo, Janssen, Ann, Buchheim, Judith-Irina, Choukèr, Alexander, Baatout, Sarah, Moreels, Marjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesiology Antigens Assaying Astronauts Bacteria Blood Blood Cells - cytology Blood Cells - immunology Cell culture Cell-mediated immunity Cytokines Cytokines - blood Cytokines - metabolism Gravitation Gravity Healthy Volunteers Humans Immune system Immunity Immunity, Cellular Immunology Infections Interferon Interleukin 10 Interleukin 2 Laboratories Lipopolysaccharides Listeria Listeria monocytogenes Lymphocytes Male Microgravity Nuclear physics Pokeweed mitogen Positioning devices (machinery) Proteomics Recall Research centers Signal transduction Stimulation Stimuli Tumor necrosis factor-TNF Tumor necrosis factor-α Weightlessness γ-Interferon
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