Differential Effects of Anesthetics and Opioid Receptor Activation on Cardioprotection Elicited by Reactive Oxygen Species–Mediated Postconditioning in Sprague-Dawley Rat Hearts

BACKGROUND:Despite an array of cardioprotective interventions identified in preclinical models of ischemia–reperfusion (IR) injury, successful clinical translation has not been achieved. This study investigated whether drugs routinely used in clinical anesthesia influence cardioprotective effectiven...

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Veröffentlicht in:	Anesthesia and analgesia 2018-05, Vol.126 (5), p.1739-1746
Hauptverfasser:	Lucchinetti, Eliana, Lou, Phing-How, Gandhi, Manoj, Clanachan, Alexander S., Zaugg, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Anesthetics, Inhalation - administration & dosage Anesthetics, Intravenous - administration & dosage Animals Heart - drug effects Heart - physiology Ischemic Postconditioning - methods Isolated Heart Preparation - methods Male Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - prevention & control Propofol - administration & dosage Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Receptors, Opioid - agonists Receptors, Opioid - metabolism Remifentanil - administration & dosage Sevoflurane - administration & dosage
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