Human parvovirus B19 nonstructural protein NS1 activates NLRP3 inflammasome signaling in adult‑onset Still's disease

Dysregulation of inflammasomes serves a pathogenic role in autoinflammatory diseases (AIDs) and adult-onset Still's disease (AOSD) has been categorized as an AID. The present study investigated the expression of NLR family pyrin domain containing proteins (NLRPs) inflammasome in patients with A...

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Veröffentlicht in:	Molecular medicine reports 2018-02, Vol.17 (2), p.3364-3371
Hauptverfasser:	Chen, Der-Yuan, Chen, Yi-Ming, Chen, Hsin-Hua, Hsieh, Chia-Wei, Gung, Ning-Rong, Hung, Wei-Ting, Tzang, Bor-Show, Hsu, Tsai-Ching
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens Arthritis Caspase Caspase-1 Cytokines Deoxyribonucleic acid Disease DNA Enzyme-linked immunosorbent assay Female Fever Gene expression Gene Expression Regulation Humans Inflammasomes Inflammasomes - genetics Inflammasomes - immunology Inflammation Interleukin 18 Juvenile rheumatoid arthritis Leukocytes (mononuclear) Male NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - immunology Parvoviridae Infections - complications Parvoviridae Infections - genetics Parvoviridae Infections - immunology Parvoviridae Infections - virology Parvovirus B19, Human - immunology Parvoviruses Pathogenesis Peripheral blood mononuclear cells Polymerase chain reaction Proteins Pyrin protein Reverse transcription Rheumatic diseases RNA, Messenger - genetics Rodents Signal Transduction Still's Disease, Adult-Onset - complications Still's Disease, Adult-Onset - genetics Still's Disease, Adult-Onset - immunology Still's Disease, Adult-Onset - virology Studies Viral infections Western blotting
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