Crosstalk between Nrf2 and YAP contributes to maintaining the antioxidant potential and chemoresistance in bladder cancer

Redox adaptation plays an important role in cancer cells drug resistance. The antioxidant response is principally mediated by the transcription factor Nrf2, that induces the transcriptional activation of several genes involved in GSH synthesis, chemoresistance, and cytoprotection. YAP is emerging as...

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Veröffentlicht in:	Free radical biology & medicine 2018-02, Vol.115, p.447-457
Hauptverfasser:	Ciamporcero, Eric, Daga, Martina, Pizzimenti, Stefania, Roetto, Antonella, Dianzani, Chiara, Compagnone, Alessandra, Palmieri, Antonietta, Ullio, Chiara, Cangemi, Luigi, Pili, Roberto, Barrera, Giuseppina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Antineoplastic Agents - pharmacology Antioxidants - metabolism Bladder cancer cells Cell Line, Tumor Chemoresistance Cisplatin - pharmacology Drug Resistance, Neoplasm - genetics Forkhead Box Protein M1 - genetics Forkhead Box Protein M1 - metabolism FOXM1 Gene Expression Regulation, Neoplastic Glutathione Humans NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 Oxidation-Reduction Oxidative Stress Phosphoproteins - genetics Phosphoproteins - metabolism Receptor Cross-Talk RNA, Small Interfering - genetics Transcription Factors Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics YAP
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