Functional therapies for cutaneous wound repair in epidermolysis bullosa
Chronic wounding as a result of recurrent skin blistering in the painful genetic skin disease epidermolysis bullosa, may lead to life-threatening infections, increased risk of tumor formation, and other serious medical complications. Therefore, epidermolysis bullosa patients have an urgent need for...
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| Veröffentlicht in: | Advanced drug delivery reviews 2018-04, Vol.129, p.330-343 |
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| creator | Peking, Patricia Koller, Ulrich Murauer, Eva M. |
| description | Chronic wounding as a result of recurrent skin blistering in the painful genetic skin disease epidermolysis bullosa, may lead to life-threatening infections, increased risk of tumor formation, and other serious medical complications. Therefore, epidermolysis bullosa patients have an urgent need for optimal wound care and tissue regeneration. Therapeutic strategies using gene-, protein-, and cell-therapies are being developed to improve clinical symptoms, and some of them have already been investigated in early clinical trials. The most favorable options of functional therapies include gene replacement, gene editing, RNA targeting, and harnessing natural gene therapy. This review describes the current progress of the different approaches targeting autologous skin cells, and will discuss the benefits and challenges of their application.
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| doi_str_mv | 10.1016/j.addr.2017.12.003 |
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| fulltext | fulltext |
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| ispartof | Advanced drug delivery reviews, 2018-04, Vol.129, p.330-343 |
| issn | 0169-409X 1872-8294 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Autologous skin cells Ex vivo therapy Genodermatoses In vivo therapy Stem cells Wound healing |
| title | Functional therapies for cutaneous wound repair in epidermolysis bullosa |
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