Niclosamide acts as a new inhibitor of vasculogenic mimicry in oral cancer through upregulation of miR-124 and downregulation of STAT3

Tumors require nutrients and oxygen for growth and metastasis. Vasculogenic mimicry (VM) has been found as a new manner of blood supply, which is characterized as the formation of tumor cell-lined vessels instead of endothelial vessels. This is why angiogenesis agents targeted to endothelial cells s...

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Veröffentlicht in:	Oncology reports 2018-02, Vol.39 (2), p.827-833
Hauptverfasser:	Li, Xiaoxu, Yang, Zhicheng, Han, Zewen, Wen, Yanhui, Ma, Zeyun, Wang, Yixiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antiparasitic agents Apoptosis Breast cancer Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Development and progression Dosage and administration Down-Regulation Drug therapy Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Genomes Health aspects Humans Liver cancer Lung cancer Medical prognosis Melanoma Metastasis Mice MicroRNA MicroRNAs - genetics Mouth cancer Mouth Neoplasms - blood supply Mouth Neoplasms - drug therapy Mouth Neoplasms - genetics Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - genetics Niclosamide - pharmacology Oral cancer Roles STAT3 STAT3 Transcription Factor - genetics Studies Tumors Up-Regulation Xenograft Model Antitumor Assays
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