Hypoxia and transforming growth factor‐beta1 pathway activation promote Chinese Hamster Ovary cell aggregation

Suspension cultivation is the preferred mode of operation for the large‐scale production of many biologics. Chinese Hamster Ovary (CHO) cells are anchorage‐dependent in origin, but they have been widely adapted to suspension culture. In suspension culture, formation of CHO cell aggregates is a commo...

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Veröffentlicht in:	Biotechnology and bioengineering 2018-04, Vol.115 (4), p.1051-1061
Hauptverfasser:	Qian, Yueming, Rehmann, Matthew S., Qian, Nan‐Xin, He, Aiqing, Borys, Michael C., Kayne, Paul S., Li, Zheng Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Agglomeration aggregation Animals Batch Cell Culture Techniques Cell aggregation Cell Aggregation - drug effects Cell culture Cell Hypoxia - drug effects CHO Cells Cricetulus Cultivation Extracellular matrix extracellular matrix protein Fibronectin Fibronectins - metabolism Gene expression Gene Expression Profiling Gene Ontology Growth factors Humans Hypoxia Oxygen - pharmacology Proteins Recombinant Proteins - pharmacology Suspension culture transcriptomics transforming growth factor beta (TGF‐β) Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1
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