STMN1, a prognostic predictor of esophageal squamous cell carcinoma, is a marker of the activation of the PI3K pathway

The esophageal squamous cell carcinoma (ESCC) subtype with STMN1 overexpression has a high likelihood of lymphatic metastatic recurrence. However, the underlying mechanism remains to be further elucidated. We assessed the expression level of STMN1 and PTEN in 96 pN0 ESCC patient tissues using immuno...

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Veröffentlicht in:	Oncology reports 2018-02, Vol.39 (2), p.834-842
Hauptverfasser:	Jiang, Wenpeng, Huang, Shiting, Song, Liang, Wang, Zhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer therapies Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Care and treatment Cell cycle Cell division Cell growth Cell Line, Tumor Cellular signal transduction Chromones - pharmacology Cytoskeletal proteins Development and progression Esophageal cancer Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Esophageal Squamous Cell Carcinoma Female Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Humans Kinases Laboratories Lymph Node Excision Lymphatic Metastasis Male Medical prognosis Metastasis Morpholines - pharmacology Neoplasm Invasiveness Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Neoplasm Staging Phosphatidylinositol 3-Kinases - metabolism Prognosis Prostate Proteins PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Signal Transduction - drug effects Squamous cell carcinoma Stathmin - genetics Stathmin - metabolism Up-Regulation
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