Synthesis and Biological Evaluation of a Degradable Trehalose Glycopolymer Prepared by RAFT Polymerization

There is a significant need for new biodegradable protein stabilizing polymers. Herein, the synthesis of a polymer with trehalose side chains and hydrolytically degradable backbone esters and its evaluation for protein stabilization and cytotoxicity are described. Specifically, an alkene‐containing...

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Veröffentlicht in:	Macromolecular rapid communications. 2018-03, Vol.39 (5), p.n/a
Hauptverfasser:	Lau, Uland Y., Pelegri‐O'Day, Emma M., Maynard, Heather D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Addition polymerization Alkenes Alkenes - chemistry Animals Biocompatibility Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biodegradability Biodegradation Biomedical materials biomimetic Cell Line, Tumor Cell Survival - drug effects Cells, Cultured Chain transfer Chains (polymeric) Chemical synthesis Cytotoxicity Degradation Esters Evaluation Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fusion protein Glycopolymers Humans Leukemia, Myeloid - pathology Leukocytes (granulocytic) Maltose Maltose-binding protein Mice Polyhistidine Polymerization Polymers Polymers - chemical synthesis Polymers - chemistry Polymers - pharmacology Proteins radical polymerization Sulfhydryl Compounds - chemistry synthesis Toxicity Trehalose Trehalose - chemistry
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