Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models

Background: The novel adamantyl retinoid ST1926 is a potent inducer of apoptosis in ovarian carcinoma cells. Since the pro-apoptotic effect is associated with activation of p53, in this study we have investigated the efficacy of combination of ST1926 with cisplatin, a DNA-damaging agent that is known to induce p53-dependent apoptosis. Materials and methods: The efficacy of ST1926 and its combination with cisplatin was evaluated in human ovarian carcinoma models, including resistant tumors. Results: Oral treatment with ST1926 alone caused a marginal tumor growth inhibition (