Autophagy limits activation of the inflammasomes

Summary Inflammasomes are multiprotein complexes that control the maturation and production of interleukin‐1 family members and play crucial roles in host defense against pathogens. However, dysregulated activation of inflammasomes is associated with intense inflammation, leading to the development...

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Veröffentlicht in:	Immunological reviews 2018-01, Vol.281 (1), p.62-73
Hauptverfasser:	Takahama, Michihiro, Akira, Shizuo, Saitoh, Tatsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Activation Autophagy cytokines Diseases endotoxin shock Homeostasis Inflammasomes inflammation inflammatory bowel disease Inflammatory diseases Interleukin 1 Machinery and equipment Phagocytosis Proteins signaling proteins toll‐like receptors/pattern recognition receptors
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