Response of serum 25(OH)D to Vitamin D and calcium supplementation in school-children from a semi-rural setting in India
•Vitamin D-Calcium supplementation (1000IU–500 mg/day) effective in achieving sufficiency.•Children with baseline 25(OH)D concentrations
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| Veröffentlicht in: | The Journal of steroid biochemistry and molecular biology 2018-06, Vol.180, p.35-40 |
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| container_title | The Journal of steroid biochemistry and molecular biology |
| container_volume | 180 |
| creator | Mandlik, Rubina Khadilkar, Anuradha Kajale, Neha Ekbote, Veena Patwardhan, Vivek Mistry, Sejal Khadilkar, Vaman Chiplonkar, Shashi |
| description | •Vitamin D-Calcium supplementation (1000IU–500 mg/day) effective in achieving sufficiency.•Children with baseline 25(OH)D concentrations |
| doi_str_mv | 10.1016/j.jsbmb.2017.12.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1977786162</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0960076017303679</els_id><sourcerecordid>2086368996</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-f0ec30d01c2c95d05792e430b5efae72a1379ed140267694a794602fed7cbd7d3</originalsourceid><addsrcrecordid>eNp90cGO1SAUBmBiNM716hOYGBI346L1QHuhLFyYGXUmmWQSo24JhVOHpoUKrdG3l-sdXbhwBYvvHMj_E_KcQc2AiddjPeZ-7msOTNaM1wDNA7JjnVQV4xwekh0oARVIAWfkSc4jFNEw-ZicccVbKTu-Iz8-Yl5iyEjjQDOmbab8cH579eqSrpF-8auZfaCX1ARHrZmsLyBvyzLhjGE1q4-BFpDtXYxTZe_85BIGOqQ4U1MWzr5KWzJTua6rD1-P-Do4b56SR4OZMj67P_fk8_t3ny6uqpvbD9cXb28q23RyrQZA24ADZrlVBwcHqTi2DfQHHAxKblgjFTrWAhdSqNZI1QrgAzppeyddsyfnp71Lit82zKuefbY4TSZg3LJmSpYkBBO80Jf_0DFuKZTfaQ6daESnlCiqOSmbYs4JB70kP5v0UzPQx2L0qH8Xo4_FaMb1MfY9eXG_e-tndH9n_jRRwJsTwBLGd49JZ-sxWHQ-oV21i_6_D_wCJJae8Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2086368996</pqid></control><display><type>article</type><title>Response of serum 25(OH)D to Vitamin D and calcium supplementation in school-children from a semi-rural setting in India</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Mandlik, Rubina ; Khadilkar, Anuradha ; Kajale, Neha ; Ekbote, Veena ; Patwardhan, Vivek ; Mistry, Sejal ; Khadilkar, Vaman ; Chiplonkar, Shashi</creator><creatorcontrib>Mandlik, Rubina ; Khadilkar, Anuradha ; Kajale, Neha ; Ekbote, Veena ; Patwardhan, Vivek ; Mistry, Sejal ; Khadilkar, Vaman ; Chiplonkar, Shashi</creatorcontrib><description>•Vitamin D-Calcium supplementation (1000IU–500 mg/day) effective in achieving sufficiency.•Children with baseline 25(OH)D concentrations <45 nmol/L experience most benefit.•Basal 25(OH)D concentrations inversely impact improvement post-supplementation.
The objectives of this study were to: 1) Determine the impact of varying baseline serum 25OHD on increase in vitamin D concentrations after daily supplementation with vitamin D and calcium (1000 IU + 500 mg respectively) for six months in school-children from a semi-rural setting 2) Test the efficacy of daily vitamin D-calcium supplementation on improvement in serum vitamin D concentrations to ≥75 nmol/L. Data collected from 106 subjects (58 boys, 48 girls), aged 6–12 years, included anthropometric measures like height and weight, body composition analysis, three one-day dietary recalls and sunlight exposure (by questionnaire). Blood was collected at baseline and endline and estimated for serum vitamin D by ELISA technique using standard kits. Classification of Vitamin D status was performed according to the 2011 Endocrine Society Practice Guidelines: vitamin D deficiency – <50 nmol/L; insufficiency – 50.0–74.9 nmol/L; sufficiency – ≥75 nmol/L. Statistical analysis was performed using SPSS software. Mean baseline serum vitamin D concentration was 59.7 ± 11.2 nmol/L; this rose to 79.8 ± 23.3 nmol/L with no significant differences between genders at the two time-points. Inverse relationship was obtained between baseline serum 25(OH)D concentrations and change in serum concentrations after supplementation, implying that with increasing baseline serum concentrations of 25(OH)D, increase in vitamin D levels post supplementation were significantly lower (r = − 0.96, p < 0.0001). Greatest benefit of change in serum vitamin D concentrations after supplementation was experienced by children with basal concentrations of <45 nmol/L. Daily vitamin D supplementation was effective in improving serum 25(OH)D to ≥75 nmol/L in 44% of children. Significantly higher percentage of children who were deficient at baseline (64%) were able to attain serum concentrations of ≥75 nmol/L as compared to children who were vitamin D insufficient (43%) (p < 0.001). Thus, daily supplementation with 1000 IU of vitamin D along with 500 mg of calcium helped in improving serum vitamin D concentrations to ≥75 nmol/L. Children who were vitamin D deficient particularly experienced these benefits.</description><identifier>ISSN: 0960-0760</identifier><identifier>EISSN: 1879-1220</identifier><identifier>DOI: 10.1016/j.jsbmb.2017.12.003</identifier><identifier>PMID: 29247782</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Biomarkers - blood ; Body composition ; Bone Diseases - blood ; Bone Diseases - drug therapy ; Bone Diseases - epidemiology ; Calcium ; Child ; Children ; Daily supplementation ; Deficiency ; Diet ; Dietary supplements ; Double-Blind Method ; Enzyme-linked immunosorbent assay ; Female ; Humans ; India - epidemiology ; Male ; Nutrient deficiency ; Nutrition ; Optimal concentrations ; Rural Population ; Schools ; Statistical analysis ; Sufficiency ; Vitamin D ; Vitamin D - administration & dosage ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - drug therapy ; Vitamin D Deficiency - epidemiology ; Vitamins - administration & dosage</subject><ispartof>The Journal of steroid biochemistry and molecular biology, 2018-06, Vol.180, p.35-40</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Jun 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-f0ec30d01c2c95d05792e430b5efae72a1379ed140267694a794602fed7cbd7d3</citedby><cites>FETCH-LOGICAL-c387t-f0ec30d01c2c95d05792e430b5efae72a1379ed140267694a794602fed7cbd7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jsbmb.2017.12.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29247782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mandlik, Rubina</creatorcontrib><creatorcontrib>Khadilkar, Anuradha</creatorcontrib><creatorcontrib>Kajale, Neha</creatorcontrib><creatorcontrib>Ekbote, Veena</creatorcontrib><creatorcontrib>Patwardhan, Vivek</creatorcontrib><creatorcontrib>Mistry, Sejal</creatorcontrib><creatorcontrib>Khadilkar, Vaman</creatorcontrib><creatorcontrib>Chiplonkar, Shashi</creatorcontrib><title>Response of serum 25(OH)D to Vitamin D and calcium supplementation in school-children from a semi-rural setting in India</title><title>The Journal of steroid biochemistry and molecular biology</title><addtitle>J Steroid Biochem Mol Biol</addtitle><description>•Vitamin D-Calcium supplementation (1000IU–500 mg/day) effective in achieving sufficiency.•Children with baseline 25(OH)D concentrations <45 nmol/L experience most benefit.•Basal 25(OH)D concentrations inversely impact improvement post-supplementation.
The objectives of this study were to: 1) Determine the impact of varying baseline serum 25OHD on increase in vitamin D concentrations after daily supplementation with vitamin D and calcium (1000 IU + 500 mg respectively) for six months in school-children from a semi-rural setting 2) Test the efficacy of daily vitamin D-calcium supplementation on improvement in serum vitamin D concentrations to ≥75 nmol/L. Data collected from 106 subjects (58 boys, 48 girls), aged 6–12 years, included anthropometric measures like height and weight, body composition analysis, three one-day dietary recalls and sunlight exposure (by questionnaire). Blood was collected at baseline and endline and estimated for serum vitamin D by ELISA technique using standard kits. Classification of Vitamin D status was performed according to the 2011 Endocrine Society Practice Guidelines: vitamin D deficiency – <50 nmol/L; insufficiency – 50.0–74.9 nmol/L; sufficiency – ≥75 nmol/L. Statistical analysis was performed using SPSS software. Mean baseline serum vitamin D concentration was 59.7 ± 11.2 nmol/L; this rose to 79.8 ± 23.3 nmol/L with no significant differences between genders at the two time-points. Inverse relationship was obtained between baseline serum 25(OH)D concentrations and change in serum concentrations after supplementation, implying that with increasing baseline serum concentrations of 25(OH)D, increase in vitamin D levels post supplementation were significantly lower (r = − 0.96, p < 0.0001). Greatest benefit of change in serum vitamin D concentrations after supplementation was experienced by children with basal concentrations of <45 nmol/L. Daily vitamin D supplementation was effective in improving serum 25(OH)D to ≥75 nmol/L in 44% of children. Significantly higher percentage of children who were deficient at baseline (64%) were able to attain serum concentrations of ≥75 nmol/L as compared to children who were vitamin D insufficient (43%) (p < 0.001). Thus, daily supplementation with 1000 IU of vitamin D along with 500 mg of calcium helped in improving serum vitamin D concentrations to ≥75 nmol/L. Children who were vitamin D deficient particularly experienced these benefits.</description><subject>Biomarkers - blood</subject><subject>Body composition</subject><subject>Bone Diseases - blood</subject><subject>Bone Diseases - drug therapy</subject><subject>Bone Diseases - epidemiology</subject><subject>Calcium</subject><subject>Child</subject><subject>Children</subject><subject>Daily supplementation</subject><subject>Deficiency</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Double-Blind Method</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Male</subject><subject>Nutrient deficiency</subject><subject>Nutrition</subject><subject>Optimal concentrations</subject><subject>Rural Population</subject><subject>Schools</subject><subject>Statistical analysis</subject><subject>Sufficiency</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - drug therapy</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamins - administration & dosage</subject><issn>0960-0760</issn><issn>1879-1220</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90cGO1SAUBmBiNM716hOYGBI346L1QHuhLFyYGXUmmWQSo24JhVOHpoUKrdG3l-sdXbhwBYvvHMj_E_KcQc2AiddjPeZ-7msOTNaM1wDNA7JjnVQV4xwekh0oARVIAWfkSc4jFNEw-ZicccVbKTu-Iz8-Yl5iyEjjQDOmbab8cH579eqSrpF-8auZfaCX1ARHrZmsLyBvyzLhjGE1q4-BFpDtXYxTZe_85BIGOqQ4U1MWzr5KWzJTua6rD1-P-Do4b56SR4OZMj67P_fk8_t3ny6uqpvbD9cXb28q23RyrQZA24ADZrlVBwcHqTi2DfQHHAxKblgjFTrWAhdSqNZI1QrgAzppeyddsyfnp71Lit82zKuefbY4TSZg3LJmSpYkBBO80Jf_0DFuKZTfaQ6daESnlCiqOSmbYs4JB70kP5v0UzPQx2L0qH8Xo4_FaMb1MfY9eXG_e-tndH9n_jRRwJsTwBLGd49JZ-sxWHQ-oV21i_6_D_wCJJae8Q</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Mandlik, Rubina</creator><creator>Khadilkar, Anuradha</creator><creator>Kajale, Neha</creator><creator>Ekbote, Veena</creator><creator>Patwardhan, Vivek</creator><creator>Mistry, Sejal</creator><creator>Khadilkar, Vaman</creator><creator>Chiplonkar, Shashi</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201806</creationdate><title>Response of serum 25(OH)D to Vitamin D and calcium supplementation in school-children from a semi-rural setting in India</title><author>Mandlik, Rubina ; 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The objectives of this study were to: 1) Determine the impact of varying baseline serum 25OHD on increase in vitamin D concentrations after daily supplementation with vitamin D and calcium (1000 IU + 500 mg respectively) for six months in school-children from a semi-rural setting 2) Test the efficacy of daily vitamin D-calcium supplementation on improvement in serum vitamin D concentrations to ≥75 nmol/L. Data collected from 106 subjects (58 boys, 48 girls), aged 6–12 years, included anthropometric measures like height and weight, body composition analysis, three one-day dietary recalls and sunlight exposure (by questionnaire). Blood was collected at baseline and endline and estimated for serum vitamin D by ELISA technique using standard kits. Classification of Vitamin D status was performed according to the 2011 Endocrine Society Practice Guidelines: vitamin D deficiency – <50 nmol/L; insufficiency – 50.0–74.9 nmol/L; sufficiency – ≥75 nmol/L. Statistical analysis was performed using SPSS software. Mean baseline serum vitamin D concentration was 59.7 ± 11.2 nmol/L; this rose to 79.8 ± 23.3 nmol/L with no significant differences between genders at the two time-points. Inverse relationship was obtained between baseline serum 25(OH)D concentrations and change in serum concentrations after supplementation, implying that with increasing baseline serum concentrations of 25(OH)D, increase in vitamin D levels post supplementation were significantly lower (r = − 0.96, p < 0.0001). Greatest benefit of change in serum vitamin D concentrations after supplementation was experienced by children with basal concentrations of <45 nmol/L. Daily vitamin D supplementation was effective in improving serum 25(OH)D to ≥75 nmol/L in 44% of children. Significantly higher percentage of children who were deficient at baseline (64%) were able to attain serum concentrations of ≥75 nmol/L as compared to children who were vitamin D insufficient (43%) (p < 0.001). Thus, daily supplementation with 1000 IU of vitamin D along with 500 mg of calcium helped in improving serum vitamin D concentrations to ≥75 nmol/L. Children who were vitamin D deficient particularly experienced these benefits.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29247782</pmid><doi>10.1016/j.jsbmb.2017.12.003</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of steroid biochemistry and molecular biology, 2018-06, Vol.180, p.35-40 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biomarkers - blood Body composition Bone Diseases - blood Bone Diseases - drug therapy Bone Diseases - epidemiology Calcium Child Children Daily supplementation Deficiency Diet Dietary supplements Double-Blind Method Enzyme-linked immunosorbent assay Female Humans India - epidemiology Male Nutrient deficiency Nutrition Optimal concentrations Rural Population Schools Statistical analysis Sufficiency Vitamin D Vitamin D - administration & dosage Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - drug therapy Vitamin D Deficiency - epidemiology Vitamins - administration & dosage |
| title | Response of serum 25(OH)D to Vitamin D and calcium supplementation in school-children from a semi-rural setting in India |
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