Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment
The application of the biphasic release profile furnished by electrospun polyblend nanofibers for local cancer treatment was investigated. By adjusting the weight ratio of the hydrophilic polymer (poly(ethylene oxide), PEO) and hydrophobic polymer (poly( l -lactide), PLA), PEO 10 -PLA 90 fibers with...
Gespeichert in:
| Veröffentlicht in: | Biomaterials science 2018-01, Vol.6 (2), p.324-331 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 331 |
|---|---|
| container_issue | 2 |
| container_start_page | 324 |
| container_title | Biomaterials science |
| container_volume | 6 |
| creator | Kuang, Gaizhen Zhang, Zhiyun Liu, Shi Zhou, Dongfang Lu, Xiaolan Jing, Xiabin Huang, Yubin |
| description | The application of the biphasic release profile furnished by electrospun polyblend nanofibers for local cancer treatment was investigated. By adjusting the weight ratio of the hydrophilic polymer (poly(ethylene oxide), PEO) and hydrophobic polymer (poly(
l
-lactide), PLA), PEO
10
-PLA
90
fibers with typical biphasic release kinetics were successfully prepared. Due to their unique release profile, PEO
10
-PLA
90
fibers can quickly access the tumor site
in vivo
at a high drug content within 1 h and keep at a high level for longer than two weeks.
In vivo
antitumor and safety studies demonstrated that PEO
10
-PLA
90
fibers can achieve optimized local cancer treatment efficacy and avoid undesired adverse reactions. The biphasic drug release profile provided by the polyblend electrospun technology was proven to be a new conception for local chemotherapy.
We report the first attempt to apply biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment. |
| doi_str_mv | 10.1039/c7bm01018d |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1977783461</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2002522250</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-50676754924fa8c7316fde6aa5f97cc7ad501443bb1c6952c04dcae775c8f83</originalsourceid><addsrcrecordid>eNpdkc1P3DAQxS3UClaUC3eQpV4Q0ra2Y2eSI7vQD4mKA9yDMxlDVkkc7OSw_etrWLqVOpd50vz09PSGsVMpvkiRlV8R6l5IIYvmgC2U0LDUhS4_7HUmjthJjBuRBqAUuTxkR6pUWhUGFuxx1Y7PNrbImzA_8UAd2UjcBd_zpHEKPo7zwEffbeuOhoYPdvCurSlE7nzgfpzavv1NDe882o6jHZACnwLZqadh-sQ-OttFOnnfx-z-283D-sfy9u77z_XV7RIzKKalETnkYHQK5myBkMncNZRba1wJiGAbI6TWWV1LzEujUOgGLQEYLFyRHbOLnesY_MtMcar6NiJ1nR3Iz7GSJQAUmc5lQj__h278HIaUrVJCKKOUMiJRlzsKUwExkKvG0PY2bCspqtfiqzWsfr0Vf53g83fLue6p2aN_a07A2Q4IEffXf5_L_gCLLof1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2002522250</pqid></control><display><type>article</type><title>Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><creator>Kuang, Gaizhen ; Zhang, Zhiyun ; Liu, Shi ; Zhou, Dongfang ; Lu, Xiaolan ; Jing, Xiabin ; Huang, Yubin</creator><creatorcontrib>Kuang, Gaizhen ; Zhang, Zhiyun ; Liu, Shi ; Zhou, Dongfang ; Lu, Xiaolan ; Jing, Xiabin ; Huang, Yubin</creatorcontrib><description>The application of the biphasic release profile furnished by electrospun polyblend nanofibers for local cancer treatment was investigated. By adjusting the weight ratio of the hydrophilic polymer (poly(ethylene oxide), PEO) and hydrophobic polymer (poly(
l
-lactide), PLA), PEO
10
-PLA
90
fibers with typical biphasic release kinetics were successfully prepared. Due to their unique release profile, PEO
10
-PLA
90
fibers can quickly access the tumor site
in vivo
at a high drug content within 1 h and keep at a high level for longer than two weeks.
In vivo
antitumor and safety studies demonstrated that PEO
10
-PLA
90
fibers can achieve optimized local cancer treatment efficacy and avoid undesired adverse reactions. The biphasic drug release profile provided by the polyblend electrospun technology was proven to be a new conception for local chemotherapy.
We report the first attempt to apply biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment.</description><identifier>ISSN: 2047-4830</identifier><identifier>EISSN: 2047-4849</identifier><identifier>DOI: 10.1039/c7bm01018d</identifier><identifier>PMID: 29242857</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Antibiotics, Antineoplastic - administration & dosage ; Antibiotics, Antineoplastic - pharmacokinetics ; Cancer ; Cancer therapies ; Cell Line, Tumor ; Chemotherapy ; Doxorubicin - administration & dosage ; Doxorubicin - pharmacokinetics ; Drug delivery systems ; Drug Liberation ; Electrospinning ; Ethylene oxide ; In vivo methods and tests ; Liver Neoplasms - drug therapy ; Male ; Mice ; Nanofibers ; Nanofibers - adverse effects ; Nanofibers - chemistry ; Polyesters - chemistry ; Polyethylene Glycols - chemistry ; Polymers ; Reaction kinetics</subject><ispartof>Biomaterials science, 2018-01, Vol.6 (2), p.324-331</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-50676754924fa8c7316fde6aa5f97cc7ad501443bb1c6952c04dcae775c8f83</citedby><cites>FETCH-LOGICAL-c378t-50676754924fa8c7316fde6aa5f97cc7ad501443bb1c6952c04dcae775c8f83</cites><orcidid>0000-0002-5212-318X ; 0000-0002-8381-7440</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29242857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuang, Gaizhen</creatorcontrib><creatorcontrib>Zhang, Zhiyun</creatorcontrib><creatorcontrib>Liu, Shi</creatorcontrib><creatorcontrib>Zhou, Dongfang</creatorcontrib><creatorcontrib>Lu, Xiaolan</creatorcontrib><creatorcontrib>Jing, Xiabin</creatorcontrib><creatorcontrib>Huang, Yubin</creatorcontrib><title>Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment</title><title>Biomaterials science</title><addtitle>Biomater Sci</addtitle><description>The application of the biphasic release profile furnished by electrospun polyblend nanofibers for local cancer treatment was investigated. By adjusting the weight ratio of the hydrophilic polymer (poly(ethylene oxide), PEO) and hydrophobic polymer (poly(
l
-lactide), PLA), PEO
10
-PLA
90
fibers with typical biphasic release kinetics were successfully prepared. Due to their unique release profile, PEO
10
-PLA
90
fibers can quickly access the tumor site
in vivo
at a high drug content within 1 h and keep at a high level for longer than two weeks.
In vivo
antitumor and safety studies demonstrated that PEO
10
-PLA
90
fibers can achieve optimized local cancer treatment efficacy and avoid undesired adverse reactions. The biphasic drug release profile provided by the polyblend electrospun technology was proven to be a new conception for local chemotherapy.
We report the first attempt to apply biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment.</description><subject>Animals</subject><subject>Antibiotics, Antineoplastic - administration & dosage</subject><subject>Antibiotics, Antineoplastic - pharmacokinetics</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cell Line, Tumor</subject><subject>Chemotherapy</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - pharmacokinetics</subject><subject>Drug delivery systems</subject><subject>Drug Liberation</subject><subject>Electrospinning</subject><subject>Ethylene oxide</subject><subject>In vivo methods and tests</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Male</subject><subject>Mice</subject><subject>Nanofibers</subject><subject>Nanofibers - adverse effects</subject><subject>Nanofibers - chemistry</subject><subject>Polyesters - chemistry</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymers</subject><subject>Reaction kinetics</subject><issn>2047-4830</issn><issn>2047-4849</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1P3DAQxS3UClaUC3eQpV4Q0ra2Y2eSI7vQD4mKA9yDMxlDVkkc7OSw_etrWLqVOpd50vz09PSGsVMpvkiRlV8R6l5IIYvmgC2U0LDUhS4_7HUmjthJjBuRBqAUuTxkR6pUWhUGFuxx1Y7PNrbImzA_8UAd2UjcBd_zpHEKPo7zwEffbeuOhoYPdvCurSlE7nzgfpzavv1NDe882o6jHZACnwLZqadh-sQ-OttFOnnfx-z-283D-sfy9u77z_XV7RIzKKalETnkYHQK5myBkMncNZRba1wJiGAbI6TWWV1LzEujUOgGLQEYLFyRHbOLnesY_MtMcar6NiJ1nR3Iz7GSJQAUmc5lQj__h278HIaUrVJCKKOUMiJRlzsKUwExkKvG0PY2bCspqtfiqzWsfr0Vf53g83fLue6p2aN_a07A2Q4IEffXf5_L_gCLLof1</recordid><startdate>20180130</startdate><enddate>20180130</enddate><creator>Kuang, Gaizhen</creator><creator>Zhang, Zhiyun</creator><creator>Liu, Shi</creator><creator>Zhou, Dongfang</creator><creator>Lu, Xiaolan</creator><creator>Jing, Xiabin</creator><creator>Huang, Yubin</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5212-318X</orcidid><orcidid>https://orcid.org/0000-0002-8381-7440</orcidid></search><sort><creationdate>20180130</creationdate><title>Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment</title><author>Kuang, Gaizhen ; Zhang, Zhiyun ; Liu, Shi ; Zhou, Dongfang ; Lu, Xiaolan ; Jing, Xiabin ; Huang, Yubin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-50676754924fa8c7316fde6aa5f97cc7ad501443bb1c6952c04dcae775c8f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Antibiotics, Antineoplastic - administration & dosage</topic><topic>Antibiotics, Antineoplastic - pharmacokinetics</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Cell Line, Tumor</topic><topic>Chemotherapy</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - pharmacokinetics</topic><topic>Drug delivery systems</topic><topic>Drug Liberation</topic><topic>Electrospinning</topic><topic>Ethylene oxide</topic><topic>In vivo methods and tests</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Male</topic><topic>Mice</topic><topic>Nanofibers</topic><topic>Nanofibers - adverse effects</topic><topic>Nanofibers - chemistry</topic><topic>Polyesters - chemistry</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polymers</topic><topic>Reaction kinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuang, Gaizhen</creatorcontrib><creatorcontrib>Zhang, Zhiyun</creatorcontrib><creatorcontrib>Liu, Shi</creatorcontrib><creatorcontrib>Zhou, Dongfang</creatorcontrib><creatorcontrib>Lu, Xiaolan</creatorcontrib><creatorcontrib>Jing, Xiabin</creatorcontrib><creatorcontrib>Huang, Yubin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuang, Gaizhen</au><au>Zhang, Zhiyun</au><au>Liu, Shi</au><au>Zhou, Dongfang</au><au>Lu, Xiaolan</au><au>Jing, Xiabin</au><au>Huang, Yubin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment</atitle><jtitle>Biomaterials science</jtitle><addtitle>Biomater Sci</addtitle><date>2018-01-30</date><risdate>2018</risdate><volume>6</volume><issue>2</issue><spage>324</spage><epage>331</epage><pages>324-331</pages><issn>2047-4830</issn><eissn>2047-4849</eissn><abstract>The application of the biphasic release profile furnished by electrospun polyblend nanofibers for local cancer treatment was investigated. By adjusting the weight ratio of the hydrophilic polymer (poly(ethylene oxide), PEO) and hydrophobic polymer (poly(
l
-lactide), PLA), PEO
10
-PLA
90
fibers with typical biphasic release kinetics were successfully prepared. Due to their unique release profile, PEO
10
-PLA
90
fibers can quickly access the tumor site
in vivo
at a high drug content within 1 h and keep at a high level for longer than two weeks.
In vivo
antitumor and safety studies demonstrated that PEO
10
-PLA
90
fibers can achieve optimized local cancer treatment efficacy and avoid undesired adverse reactions. The biphasic drug release profile provided by the polyblend electrospun technology was proven to be a new conception for local chemotherapy.
We report the first attempt to apply biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>29242857</pmid><doi>10.1039/c7bm01018d</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5212-318X</orcidid><orcidid>https://orcid.org/0000-0002-8381-7440</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2047-4830 |
| ispartof | Biomaterials science, 2018-01, Vol.6 (2), p.324-331 |
| issn | 2047-4830 2047-4849 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1977783461 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - pharmacokinetics Cancer Cancer therapies Cell Line, Tumor Chemotherapy Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Drug delivery systems Drug Liberation Electrospinning Ethylene oxide In vivo methods and tests Liver Neoplasms - drug therapy Male Mice Nanofibers Nanofibers - adverse effects Nanofibers - chemistry Polyesters - chemistry Polyethylene Glycols - chemistry Polymers Reaction kinetics |
| title | Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T05%3A40%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biphasic%20drug%20release%20from%20electrospun%20polyblend%20nanofibers%20for%20optimized%20local%20cancer%20treatment&rft.jtitle=Biomaterials%20science&rft.au=Kuang,%20Gaizhen&rft.date=2018-01-30&rft.volume=6&rft.issue=2&rft.spage=324&rft.epage=331&rft.pages=324-331&rft.issn=2047-4830&rft.eissn=2047-4849&rft_id=info:doi/10.1039/c7bm01018d&rft_dat=%3Cproquest_cross%3E2002522250%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2002522250&rft_id=info:pmid/29242857&rfr_iscdi=true |