Deoxynucleosides with benzimidazoles as aglycone moiety are potent anticancer agents

Abnormally high levels of CK2 and PIM-1 serine/threonine kinases have been documented in many cases of cancer. The elevation of CK2 and PIM-1 in cells entails suppression of apoptosis and implies a protective role for the kinases against cell death. Downregulation of these enzymes by chemical method...

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Veröffentlicht in:	European journal of pharmacology 2018-02, Vol.820, p.146-155
Hauptverfasser:	Koronkiewicz, Mirosława, Chilmonczyk, Zdzisław, Kazimerczuk, Zygmunt, Orzeszko, Andrzej
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer effects Flow cytometry Protein kinase inhibitors Tetrahalobenzimidazoles
Online-Zugang:	Volltext
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