BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis
Sepsis is an aggressive and life-threatening systemic inflammatory response with a high mortality. Inflammation and coagulation play crucial roles in the pathogenesis of sepsis in a mutually promoting manner. Unlike other single-target molecular therapies that have no obvious effects on clinical sep...
Gespeichert in:
| Veröffentlicht in: | Journal of cell science 2018-02, Vol.131 (3), p.jcs211151-jcs211151 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | jcs211151 |
|---|---|
| container_issue | 3 |
| container_start_page | jcs211151 |
| container_title | Journal of cell science |
| container_volume | 131 |
| creator | Xu, Shunyao Zhou, Zhen Li, Hao Liu, Ziying Pan, Xiaojun Wang, Fen Huang, Yueyue Li, Xiaogang Xiao, Yunbei Pan, Jingye Wang, Cong Li, Dequan |
| description | Sepsis is an aggressive and life-threatening systemic inflammatory response with a high mortality. Inflammation and coagulation play crucial roles in the pathogenesis of sepsis in a mutually promoting manner. Unlike other single-target molecular therapies that have no obvious effects on clinical sepsis, bone marrow stromal cell (BMSC) therapy offers a broader spectrum of activities ranging from immune and inflammation suppression to tissue regeneration. In this report, we demonstrate that BMSC injection attenuates septic coagulopathy. It decreased the mortality, mitigated lung injury and reduced the surge of proinflammatory factors in mice with sepsis induced by cecal ligation and puncture (CLP). An
cell model also revealed that co-culture with BMSCs reduced secretion of proinflammatory factors and injury of endothelial cells in response to lipopolysaccharide (LPS), an endotoxin of gram-negative bacteria. Together, our results demonstrate that BMSCs suppress sepsis-induced inflammation, endothelial dysfunction and defective coagulation. |
| doi_str_mv | 10.1242/jcs.211151 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1977782544</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1977782544</sourcerecordid><originalsourceid>FETCH-LOGICAL-c315t-3294c0317ae70595289f9576a3f119bbc4e9660625e4cd6a5ea856ea327e6c933</originalsourceid><addsrcrecordid>eNpdkU1LxDAQhoMo7vpx8QdIwIsIXTNJ02yOuvgFigf1XLLpdM3SpjVpDvvv7bLqwdMwwzMvwzyEnAGbAc_59drGGQcACXtkCrlSmQah9smUMQ6ZlkJMyFGMa8aY4lodkgnX4x7n8ynxty9vi0hNi43rghmQRuwHZ6ntzCo1XW-Gzw1dbmhMfR8wRudX1Pm6MW1rBtf5saEWrWlo41a7ifEV7ZO3QwqYOV8li9U2Nrp4Qg5q00Q8_anH5OP-7n3xmD2_Pjwtbp4zK0AOmeA6t0yAMqiY1JLPda2lKoyoAfRyaXPURcEKLjG3VWEkmrks0AiusLBaiGNyucvtQ_eVMA5l66LFpjEeuxRL0EqpOZd5PqIX_9B1l4Ifrys5Y4UGpXIYqasdZUMXY8C67INrTdiUwMqthXK0UO4sjPD5T2Ratlj9ob9vF99TWoLV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2006917741</pqid></control><display><type>article</type><title>BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis</title><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Company of Biologists</source><creator>Xu, Shunyao ; Zhou, Zhen ; Li, Hao ; Liu, Ziying ; Pan, Xiaojun ; Wang, Fen ; Huang, Yueyue ; Li, Xiaogang ; Xiao, Yunbei ; Pan, Jingye ; Wang, Cong ; Li, Dequan</creator><creatorcontrib>Xu, Shunyao ; Zhou, Zhen ; Li, Hao ; Liu, Ziying ; Pan, Xiaojun ; Wang, Fen ; Huang, Yueyue ; Li, Xiaogang ; Xiao, Yunbei ; Pan, Jingye ; Wang, Cong ; Li, Dequan</creatorcontrib><description>Sepsis is an aggressive and life-threatening systemic inflammatory response with a high mortality. Inflammation and coagulation play crucial roles in the pathogenesis of sepsis in a mutually promoting manner. Unlike other single-target molecular therapies that have no obvious effects on clinical sepsis, bone marrow stromal cell (BMSC) therapy offers a broader spectrum of activities ranging from immune and inflammation suppression to tissue regeneration. In this report, we demonstrate that BMSC injection attenuates septic coagulopathy. It decreased the mortality, mitigated lung injury and reduced the surge of proinflammatory factors in mice with sepsis induced by cecal ligation and puncture (CLP). An
cell model also revealed that co-culture with BMSCs reduced secretion of proinflammatory factors and injury of endothelial cells in response to lipopolysaccharide (LPS), an endotoxin of gram-negative bacteria. Together, our results demonstrate that BMSCs suppress sepsis-induced inflammation, endothelial dysfunction and defective coagulation.</description><identifier>ISSN: 0021-9533</identifier><identifier>EISSN: 1477-9137</identifier><identifier>DOI: 10.1242/jcs.211151</identifier><identifier>PMID: 29242228</identifier><language>eng</language><publisher>England: The Company of Biologists Ltd</publisher><subject>Bone marrow ; Cecum ; Cell culture ; Coagulation ; Endothelial cells ; Gram-negative bacteria ; Inflammation ; Inflammatory response ; Injection ; Injury prevention ; Lipopolysaccharides ; Lungs ; Mortality ; Pathogenesis ; Regeneration ; Rodents ; Sepsis ; Tissue engineering</subject><ispartof>Journal of cell science, 2018-02, Vol.131 (3), p.jcs211151-jcs211151</ispartof><rights>2018. Published by The Company of Biologists Ltd.</rights><rights>Copyright The Company of Biologists Ltd Feb 1, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-3294c0317ae70595289f9576a3f119bbc4e9660625e4cd6a5ea856ea327e6c933</citedby><cites>FETCH-LOGICAL-c315t-3294c0317ae70595289f9576a3f119bbc4e9660625e4cd6a5ea856ea327e6c933</cites><orcidid>0000-0001-8932-0083 ; 0000-0002-9011-7565 ; 0000-0001-7087-7359 ; 0000-0002-2367-1275 ; 0000-0003-2051-4159 ; 0000-0002-2833-5262 ; 0000-0001-6227-6692 ; 0000-0001-7703-3984 ; 0000-0002-7488-2187 ; 0000-0002-2184-6879 ; 0000-0002-2012-5148 ; 0000-0003-0556-7607</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3664,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29242228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Shunyao</creatorcontrib><creatorcontrib>Zhou, Zhen</creatorcontrib><creatorcontrib>Li, Hao</creatorcontrib><creatorcontrib>Liu, Ziying</creatorcontrib><creatorcontrib>Pan, Xiaojun</creatorcontrib><creatorcontrib>Wang, Fen</creatorcontrib><creatorcontrib>Huang, Yueyue</creatorcontrib><creatorcontrib>Li, Xiaogang</creatorcontrib><creatorcontrib>Xiao, Yunbei</creatorcontrib><creatorcontrib>Pan, Jingye</creatorcontrib><creatorcontrib>Wang, Cong</creatorcontrib><creatorcontrib>Li, Dequan</creatorcontrib><title>BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis</title><title>Journal of cell science</title><addtitle>J Cell Sci</addtitle><description>Sepsis is an aggressive and life-threatening systemic inflammatory response with a high mortality. Inflammation and coagulation play crucial roles in the pathogenesis of sepsis in a mutually promoting manner. Unlike other single-target molecular therapies that have no obvious effects on clinical sepsis, bone marrow stromal cell (BMSC) therapy offers a broader spectrum of activities ranging from immune and inflammation suppression to tissue regeneration. In this report, we demonstrate that BMSC injection attenuates septic coagulopathy. It decreased the mortality, mitigated lung injury and reduced the surge of proinflammatory factors in mice with sepsis induced by cecal ligation and puncture (CLP). An
cell model also revealed that co-culture with BMSCs reduced secretion of proinflammatory factors and injury of endothelial cells in response to lipopolysaccharide (LPS), an endotoxin of gram-negative bacteria. Together, our results demonstrate that BMSCs suppress sepsis-induced inflammation, endothelial dysfunction and defective coagulation.</description><subject>Bone marrow</subject><subject>Cecum</subject><subject>Cell culture</subject><subject>Coagulation</subject><subject>Endothelial cells</subject><subject>Gram-negative bacteria</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Injection</subject><subject>Injury prevention</subject><subject>Lipopolysaccharides</subject><subject>Lungs</subject><subject>Mortality</subject><subject>Pathogenesis</subject><subject>Regeneration</subject><subject>Rodents</subject><subject>Sepsis</subject><subject>Tissue engineering</subject><issn>0021-9533</issn><issn>1477-9137</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkU1LxDAQhoMo7vpx8QdIwIsIXTNJ02yOuvgFigf1XLLpdM3SpjVpDvvv7bLqwdMwwzMvwzyEnAGbAc_59drGGQcACXtkCrlSmQah9smUMQ6ZlkJMyFGMa8aY4lodkgnX4x7n8ynxty9vi0hNi43rghmQRuwHZ6ntzCo1XW-Gzw1dbmhMfR8wRudX1Pm6MW1rBtf5saEWrWlo41a7ifEV7ZO3QwqYOV8li9U2Nrp4Qg5q00Q8_anH5OP-7n3xmD2_Pjwtbp4zK0AOmeA6t0yAMqiY1JLPda2lKoyoAfRyaXPURcEKLjG3VWEkmrks0AiusLBaiGNyucvtQ_eVMA5l66LFpjEeuxRL0EqpOZd5PqIX_9B1l4Ifrys5Y4UGpXIYqasdZUMXY8C67INrTdiUwMqthXK0UO4sjPD5T2Ratlj9ob9vF99TWoLV</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Xu, Shunyao</creator><creator>Zhou, Zhen</creator><creator>Li, Hao</creator><creator>Liu, Ziying</creator><creator>Pan, Xiaojun</creator><creator>Wang, Fen</creator><creator>Huang, Yueyue</creator><creator>Li, Xiaogang</creator><creator>Xiao, Yunbei</creator><creator>Pan, Jingye</creator><creator>Wang, Cong</creator><creator>Li, Dequan</creator><general>The Company of Biologists Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8932-0083</orcidid><orcidid>https://orcid.org/0000-0002-9011-7565</orcidid><orcidid>https://orcid.org/0000-0001-7087-7359</orcidid><orcidid>https://orcid.org/0000-0002-2367-1275</orcidid><orcidid>https://orcid.org/0000-0003-2051-4159</orcidid><orcidid>https://orcid.org/0000-0002-2833-5262</orcidid><orcidid>https://orcid.org/0000-0001-6227-6692</orcidid><orcidid>https://orcid.org/0000-0001-7703-3984</orcidid><orcidid>https://orcid.org/0000-0002-7488-2187</orcidid><orcidid>https://orcid.org/0000-0002-2184-6879</orcidid><orcidid>https://orcid.org/0000-0002-2012-5148</orcidid><orcidid>https://orcid.org/0000-0003-0556-7607</orcidid></search><sort><creationdate>20180201</creationdate><title>BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis</title><author>Xu, Shunyao ; Zhou, Zhen ; Li, Hao ; Liu, Ziying ; Pan, Xiaojun ; Wang, Fen ; Huang, Yueyue ; Li, Xiaogang ; Xiao, Yunbei ; Pan, Jingye ; Wang, Cong ; Li, Dequan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-3294c0317ae70595289f9576a3f119bbc4e9660625e4cd6a5ea856ea327e6c933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bone marrow</topic><topic>Cecum</topic><topic>Cell culture</topic><topic>Coagulation</topic><topic>Endothelial cells</topic><topic>Gram-negative bacteria</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Injection</topic><topic>Injury prevention</topic><topic>Lipopolysaccharides</topic><topic>Lungs</topic><topic>Mortality</topic><topic>Pathogenesis</topic><topic>Regeneration</topic><topic>Rodents</topic><topic>Sepsis</topic><topic>Tissue engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Shunyao</creatorcontrib><creatorcontrib>Zhou, Zhen</creatorcontrib><creatorcontrib>Li, Hao</creatorcontrib><creatorcontrib>Liu, Ziying</creatorcontrib><creatorcontrib>Pan, Xiaojun</creatorcontrib><creatorcontrib>Wang, Fen</creatorcontrib><creatorcontrib>Huang, Yueyue</creatorcontrib><creatorcontrib>Li, Xiaogang</creatorcontrib><creatorcontrib>Xiao, Yunbei</creatorcontrib><creatorcontrib>Pan, Jingye</creatorcontrib><creatorcontrib>Wang, Cong</creatorcontrib><creatorcontrib>Li, Dequan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cell science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Shunyao</au><au>Zhou, Zhen</au><au>Li, Hao</au><au>Liu, Ziying</au><au>Pan, Xiaojun</au><au>Wang, Fen</au><au>Huang, Yueyue</au><au>Li, Xiaogang</au><au>Xiao, Yunbei</au><au>Pan, Jingye</au><au>Wang, Cong</au><au>Li, Dequan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis</atitle><jtitle>Journal of cell science</jtitle><addtitle>J Cell Sci</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>131</volume><issue>3</issue><spage>jcs211151</spage><epage>jcs211151</epage><pages>jcs211151-jcs211151</pages><issn>0021-9533</issn><eissn>1477-9137</eissn><abstract>Sepsis is an aggressive and life-threatening systemic inflammatory response with a high mortality. Inflammation and coagulation play crucial roles in the pathogenesis of sepsis in a mutually promoting manner. Unlike other single-target molecular therapies that have no obvious effects on clinical sepsis, bone marrow stromal cell (BMSC) therapy offers a broader spectrum of activities ranging from immune and inflammation suppression to tissue regeneration. In this report, we demonstrate that BMSC injection attenuates septic coagulopathy. It decreased the mortality, mitigated lung injury and reduced the surge of proinflammatory factors in mice with sepsis induced by cecal ligation and puncture (CLP). An
cell model also revealed that co-culture with BMSCs reduced secretion of proinflammatory factors and injury of endothelial cells in response to lipopolysaccharide (LPS), an endotoxin of gram-negative bacteria. Together, our results demonstrate that BMSCs suppress sepsis-induced inflammation, endothelial dysfunction and defective coagulation.</abstract><cop>England</cop><pub>The Company of Biologists Ltd</pub><pmid>29242228</pmid><doi>10.1242/jcs.211151</doi><orcidid>https://orcid.org/0000-0001-8932-0083</orcidid><orcidid>https://orcid.org/0000-0002-9011-7565</orcidid><orcidid>https://orcid.org/0000-0001-7087-7359</orcidid><orcidid>https://orcid.org/0000-0002-2367-1275</orcidid><orcidid>https://orcid.org/0000-0003-2051-4159</orcidid><orcidid>https://orcid.org/0000-0002-2833-5262</orcidid><orcidid>https://orcid.org/0000-0001-6227-6692</orcidid><orcidid>https://orcid.org/0000-0001-7703-3984</orcidid><orcidid>https://orcid.org/0000-0002-7488-2187</orcidid><orcidid>https://orcid.org/0000-0002-2184-6879</orcidid><orcidid>https://orcid.org/0000-0002-2012-5148</orcidid><orcidid>https://orcid.org/0000-0003-0556-7607</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9533 |
| ispartof | Journal of cell science, 2018-02, Vol.131 (3), p.jcs211151-jcs211151 |
| issn | 0021-9533 1477-9137 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1977782544 |
| source | EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Bone marrow Cecum Cell culture Coagulation Endothelial cells Gram-negative bacteria Inflammation Inflammatory response Injection Injury prevention Lipopolysaccharides Lungs Mortality Pathogenesis Regeneration Rodents Sepsis Tissue engineering |
| title | BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T22%3A22%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=BMSCs%20ameliorate%20septic%20coagulopathy%20by%20suppressing%20inflammation%20in%20cecal%20ligation%20and%20puncture-induced%20sepsis&rft.jtitle=Journal%20of%20cell%20science&rft.au=Xu,%20Shunyao&rft.date=2018-02-01&rft.volume=131&rft.issue=3&rft.spage=jcs211151&rft.epage=jcs211151&rft.pages=jcs211151-jcs211151&rft.issn=0021-9533&rft.eissn=1477-9137&rft_id=info:doi/10.1242/jcs.211151&rft_dat=%3Cproquest_cross%3E1977782544%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2006917741&rft_id=info:pmid/29242228&rfr_iscdi=true |