DNA structural basis for fragility at peak III of BCL2 major breakpoint region associated with t(14;18) translocation

Maintaining genome integrity is crucial for normal cellular functions. DNA double-strand breaks (DSBs), when unrepaired, can potentiate chromosomal translocations. t(14;18) translocation involving BCL2 gene on chromosome 18 and IgH loci at chromosome 14, could lead to follicular lymphoma. Molecular...

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Veröffentlicht in:	Biochimica et biophysica acta. General subjects 2018-03, Vol.1862 (3), p.649-659
Hauptverfasser:	Javadekar, Saniya M., Yadav, Rakhee, Raghavan, Sathees C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell Line, Tumor Cell Transformation, Neoplastic - genetics Chromosomal Instability - genetics Chromosomal translocation Chromosome Breakpoints Chromosome Fragile Sites - genetics Chromosomes, Human, Pair 14 - genetics Chromosomes, Human, Pair 14 - ultrastructure Chromosomes, Human, Pair 18 - genetics Chromosomes, Human, Pair 18 - ultrastructure Circular Dichroism Cruciform DNA DNA, Cruciform - analysis DNA, Cruciform - genetics Double-strand break Electrophoresis, Polyacrylamide Gel Follicular lymphoma Genetic Predisposition to Disease Genomic instability Humans Leukemia, B-Cell - pathology Models, Genetic Non-B DNA structure Proto-Oncogene Proteins c-bcl-2 - genetics Transcription, Genetic - genetics Translocation, Genetic
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