Quantification of Methadone and Main Metabolites in Nails

Abstract The quantification of drugs of abuse in keratinized matrices is becoming of special relevance for monitoring consumption and for post-mortem investigations. We aimed to implement an analytical method for the simultaneous detection of morphine (MORF), 6-monoacetylmorphine (6-MAM), methadone...

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Veröffentlicht in:	Journal of analytical toxicology 2018-04, Vol.42 (3), p.192-206
Hauptverfasser:	Magalhães, Teresa Patrícia, Cravo, Sara, Silva, Diana Dias da, Dinis-Oliveira, Ricardo Jorge, Afonso, Carlos, Lourdes Bastos, Maria de, Carmo, Helena
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analgesics, Opioid - metabolism Analgesics, Opioid - therapeutic use Analgesics, Opioid - urine Biotransformation Chromatography, Ion Exchange Drug Monitoring - methods Drug Monitoring - standards Female Gas Chromatography-Mass Spectrometry Heroin Dependence - diagnosis Heroin Dependence - metabolism Heroin Dependence - rehabilitation Heroin Dependence - urine Humans Limit of Detection Linear Models Male Methadone - metabolism Methadone - therapeutic use Methadone - urine Middle Aged Nails - metabolism Opiate Substitution Treatment - methods Predictive Value of Tests Reproducibility of Results Solid Phase Extraction Substance Abuse Detection - methods Substance Abuse Detection - standards
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