Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors

The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different...

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Veröffentlicht in:	Biomarkers in medicine 2018-01, Vol.12 (1), p.35-44
Hauptverfasser:	Abrahao-Machado, Lucas Faria, Antunes, Bruno, Filippi, Renee Zon, Volc, Sahlua, Boldrini, Erica, Menezes, Weder P, Reis, Rui M, de Camargo, Olavo Pires
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Methylthioadenosine phosphorylase Adolescent Adult Aged Biomarkers Biomarkers, Tumor - metabolism Child Child, Preschool Children & youth Ciências Médicas Disease ESFT Ethics Ewing sarcoma family of tumors Ewing's sarcoma Ewings sarcoma Female Genes Hospitals Humans Immunohistochemistry Lung cancer Male Medical prognosis Medicina Básica Methylthioadenosine phosphorylase Middle Aged MTAP Multivariate Analysis Neoplasia Pathology Phosphorylase Polyamines Prognosis Purine-Nucleoside Phosphorylase - metabolism Sarcoma, Ewing - metabolism Sarcoma, Ewing - mortality Sarcoma, Ewing - pathology Science & Technology Soft tissues Tissue Array Analysis Tumors Young Adult
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