Identification of Mn super(2+)-binding Aspartates from alpha , beta , and gamma Subunits of Human NAD-dependent Isocitrate Dehydrogenase

The human NAD-dependent isocitrate dehydrogenase (IDH), with three types of subunits present in the ratio of 2 alpha :1 beta :1 gamma , requires a divalent metal ion to catalyze the oxidative decarboxylation of isocitrate. With the aim of identifying ligands of the enzyme-bound Mn super(2+), we muta...

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Veröffentlicht in:	The Journal of biological chemistry 2006-07, Vol.281 (30), p.21073-21081
Hauptverfasser:	Soundar, Sambanthamurthy, O'Hagan, Molly, Fomulu, Kenneth S, Colman, Roberta F
Format:	Artikel
Sprache:	eng
Schlagworte:	Escherichia coli
Online-Zugang:	Volltext
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