Asparaginase production by a recombinant Pichia pastoris strain harbouring Saccharomyces cerevisiae ASP3 gene

The therapeutic enzyme asparaginase, which is used for the treatment of acute lymphoblastic leukaemia, is industrially produced by the bacteria Escherichia coli or Erwinia crysanthemi. In spite of its effectiveness as a therapeutic agent, the drug causes severe immunological reactions. As asparagina...

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Veröffentlicht in:	Enzyme and microbial technology 2006-11, Vol.39 (7), p.1457-1463
Hauptverfasser:	Ferrara, Maria Antonieta, Severino, Neuza M.B., Mansure, José João, Martins, Adriana Sotero, Oliveira, Edna M.M., Siani, Antonio Carlos, Pereira, Nei, Torres, Fernando A.G., Bon, Elba P.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-leukaemic enzyme ASP3 gene Asparaginase Biological and medical sciences Biotechnology Erwinia Escherichia coli Fundamental and applied biological sciences. Psychology Pichia pastoris Saccharomyces cerevisiae Therapeutic enzyme
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