Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus

The failure of pharmacological approaches to cure infection with the human immunodeficiency virus (HIV) has renewed the interest in gene-based therapies. Among the various strategies that are currently explored, the blockade of HIV entry into susceptible T cells and macrophages promises to be the mo...

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Veröffentlicht in:	Gene therapy 2006-07, Vol.13 (13), p.1037-1047
Hauptverfasser:	Schambach, A, Schiedlmeier, B, Kühlcke, K, Verstegen, M, Margison, G P, Li, Z, Kamino, K, Bohne, J, Alexandrov, A, Hermann, F G, von Laer, D, Baum, C
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - administration & dosage AIDS Vaccines - genetics Alkylating agents Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animal models Animals Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Bone marrow transplantation Care and treatment Cell Biology Clinical trials DNA methyltransferase Flow Cytometry Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Genetic aspects Genetic markers Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Health aspects Health. Pharmaceutical industry Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Hematopoietic Stem Cells - metabolism HIV HIV Fusion Inhibitors - therapeutic use HIV infection HIV Infections - metabolism HIV Infections - prevention & control HIV-1 Human Genetics Human immunodeficiency virus Human viral diseases Immune system Industrial applications and implications. Economical aspects Infectious diseases Leukocytes (mononuclear) Lymphocytes T Macrophages Male Medical sciences Methods Methylguanine Mice Mice, Inbred C57BL Models, Animal Nanotechnology O-Methylguanine-DNA Methyltransferase - analysis O6-methylguanine-DNA methyltransferase original-article Pharmacology Physiological aspects Retroviridae - genetics Stem cell transplantation Stem cells Toxicity Transduction, Genetic - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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