Activation of Ras Up-regulates Pro-apoptotic BNIP3 in Nitric Oxide-induced Cell Death

Nitric oxide (NO) produced by NO synthases causes nitration and nitrosylation of cellular factors. We have shown previously that endogenously produced or exogenously added NO induces expression of BNIP3 (Bcl-2/adenovirus E1B 19kDa-interacting protein 3), leading to death of macrophages (Yook, Y.-H.,...

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Veröffentlicht in:	The Journal of biological chemistry 2006-11, Vol.281 (45), p.33939-33948
Hauptverfasser:	An, Hyun-Jung, Maeng, Oky, Kang, Kyoung-Hee, Lee, Jie-Oh, Kim, Young-Sang, Paik, Sang-Gi, Lee, Hayyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Animals Apoptosis - drug effects Apoptosis - physiology Blotting, Western Cells, Cultured Enzyme Inhibitors - pharmacology Extracellular Signal-Regulated MAP Kinases Gene Expression Regulation Guanylate Cyclase - metabolism Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit Kidney - cytology Kidney - drug effects Kidney - metabolism Luciferases Macrophages - cytology Macrophages - drug effects Macrophages - metabolism MAP Kinase Kinase Kinases - antagonists & inhibitors MAP Kinase Kinase Kinases - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice Microscopy, Fluorescence Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Nitric Oxide - toxicity Nitroso Compounds - pharmacology Phosphatidylinositol 3-Kinases Plasmids - genetics Promoter Regions, Genetic - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism ras Proteins - genetics ras Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - drug effects Up-Regulation
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