Maternal Use of Oral Contraceptives and Risk of Hypospadias: A Population-Based Case-Control Study
The aim of this population-based case-control study was to examine the risk of isolated hypospadias in boys born to mothers who have used oral contraceptives in early pregnancy. The study was based on data from the Hungarian Case-Control Surveillance of Congenital Abnormalities from 1980 to 1996, an...
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| Veröffentlicht in: | European journal of epidemiology 2006-10, Vol.21 (10), p.777-781 |
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| container_title | European journal of epidemiology |
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| creator | Wogelius, Pia Horváth-Puho, Erzsébet Pedersen, Lars Nørgaard, Mette Czeizel, Andrew E. Sørensen, Henrik Toft |
| description | The aim of this population-based case-control study was to examine the risk of isolated hypospadias in boys born to mothers who have used oral contraceptives in early pregnancy. The study was based on data from the Hungarian Case-Control Surveillance of Congenital Abnormalities from 1980 to 1996, and included 3,038 boys with hypospadias (cases), 24,799 boys without congenital abnormalities (CA-free controls), and 11,881 boys with abnormalities other than hypospadias. We used unconditional logistic regression to adjust for birth order, maternal age, maternal employment status, maternal diabetes, and pre-eclampsia. When comparing cases with CA-free controls the OR for maternal use of OC was 1.21 (95% CI: 0.67-2.17). When comparing cases with boys with other abnormalities, the OR for maternal use of OC was 0.83 (95% CI: 0.46-1.50). Our data showed that self-reported maternal use of oral contraceptives during pregnancy was not associated with an increased risk of hypospadias in the offspring. |
| doi_str_mv | 10.1007/s10654-006-9067-0 |
| format | Article |
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The study was based on data from the Hungarian Case-Control Surveillance of Congenital Abnormalities from 1980 to 1996, and included 3,038 boys with hypospadias (cases), 24,799 boys without congenital abnormalities (CA-free controls), and 11,881 boys with abnormalities other than hypospadias. We used unconditional logistic regression to adjust for birth order, maternal age, maternal employment status, maternal diabetes, and pre-eclampsia. When comparing cases with CA-free controls the OR for maternal use of OC was 1.21 (95% CI: 0.67-2.17). When comparing cases with boys with other abnormalities, the OR for maternal use of OC was 0.83 (95% CI: 0.46-1.50). Our data showed that self-reported maternal use of oral contraceptives during pregnancy was not associated with an increased risk of hypospadias in the offspring.</description><identifier>ISSN: 0393-2990</identifier><identifier>EISSN: 1573-7284</identifier><identifier>DOI: 10.1007/s10654-006-9067-0</identifier><identifier>PMID: 17077991</identifier><identifier>CODEN: EJEPE8</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Abnormalities, Drug-Induced - epidemiology ; Adult ; Biological and medical sciences ; Birth control ; Birth defects ; Boys ; Case control studies ; Case studies ; Children ; Contraceptives ; Contraceptives, Oral - adverse effects ; Diabetes ; Epidemiology ; Etiology ; Female ; General aspects ; Gynecology. Andrology. Obstetrics ; Humans ; Hungary - epidemiology ; Hypospadias ; Hypospadias - chemically induced ; Hypospadias - epidemiology ; Infant, Newborn ; Logistic Models ; Male ; Male genital diseases ; Malformations of the urinary system ; Medical sciences ; Mothers ; Nephrology. Urinary tract diseases ; Non tumoral diseases ; Offspring ; Oral contraceptives ; Pregnancy ; Pregnancy Trimester, First ; Prenatal care ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Teratology ; Urinary tract. Prostate gland</subject><ispartof>European journal of epidemiology, 2006-10, Vol.21 (10), p.777-781</ispartof><rights>Copyright 2006 Springer</rights><rights>2007 INIST-CNRS</rights><rights>Springer Science+Business Media B.V. 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-8e06cece5d0a8c15cd0cf0a288205c6f8c9857dae8d401db3491d37fc4da3fff3</citedby><cites>FETCH-LOGICAL-c409t-8e06cece5d0a8c15cd0cf0a288205c6f8c9857dae8d401db3491d37fc4da3fff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/20445759$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/20445759$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,27925,27926,58018,58251</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18352958$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17077991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wogelius, Pia</creatorcontrib><creatorcontrib>Horváth-Puho, Erzsébet</creatorcontrib><creatorcontrib>Pedersen, Lars</creatorcontrib><creatorcontrib>Nørgaard, Mette</creatorcontrib><creatorcontrib>Czeizel, Andrew E.</creatorcontrib><creatorcontrib>Sørensen, Henrik Toft</creatorcontrib><title>Maternal Use of Oral Contraceptives and Risk of Hypospadias: A Population-Based Case-Control Study</title><title>European journal of epidemiology</title><addtitle>Eur J Epidemiol</addtitle><description>The aim of this population-based case-control study was to examine the risk of isolated hypospadias in boys born to mothers who have used oral contraceptives in early pregnancy. The study was based on data from the Hungarian Case-Control Surveillance of Congenital Abnormalities from 1980 to 1996, and included 3,038 boys with hypospadias (cases), 24,799 boys without congenital abnormalities (CA-free controls), and 11,881 boys with abnormalities other than hypospadias. We used unconditional logistic regression to adjust for birth order, maternal age, maternal employment status, maternal diabetes, and pre-eclampsia. When comparing cases with CA-free controls the OR for maternal use of OC was 1.21 (95% CI: 0.67-2.17). When comparing cases with boys with other abnormalities, the OR for maternal use of OC was 0.83 (95% CI: 0.46-1.50). Our data showed that self-reported maternal use of oral contraceptives during pregnancy was not associated with an increased risk of hypospadias in the offspring.</description><subject>Abnormalities, Drug-Induced - epidemiology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Birth defects</subject><subject>Boys</subject><subject>Case control studies</subject><subject>Case studies</subject><subject>Children</subject><subject>Contraceptives</subject><subject>Contraceptives, Oral - adverse effects</subject><subject>Diabetes</subject><subject>Epidemiology</subject><subject>Etiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hungary - epidemiology</subject><subject>Hypospadias</subject><subject>Hypospadias - chemically induced</subject><subject>Hypospadias - epidemiology</subject><subject>Infant, Newborn</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Malformations of the urinary system</subject><subject>Medical sciences</subject><subject>Mothers</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Non tumoral diseases</subject><subject>Offspring</subject><subject>Oral contraceptives</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Prenatal care</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Teratology</subject><subject>Urinary tract. 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| ispartof | European journal of epidemiology, 2006-10, Vol.21 (10), p.777-781 |
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| subjects | Abnormalities, Drug-Induced - epidemiology Adult Biological and medical sciences Birth control Birth defects Boys Case control studies Case studies Children Contraceptives Contraceptives, Oral - adverse effects Diabetes Epidemiology Etiology Female General aspects Gynecology. Andrology. Obstetrics Humans Hungary - epidemiology Hypospadias Hypospadias - chemically induced Hypospadias - epidemiology Infant, Newborn Logistic Models Male Male genital diseases Malformations of the urinary system Medical sciences Mothers Nephrology. Urinary tract diseases Non tumoral diseases Offspring Oral contraceptives Pregnancy Pregnancy Trimester, First Prenatal care Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Teratology Urinary tract. Prostate gland |
| title | Maternal Use of Oral Contraceptives and Risk of Hypospadias: A Population-Based Case-Control Study |
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