Transforming Growth Factor-α Inhibits the Intrinsic Pathway of c-Myc-Induced Apoptosis through Activation of Nuclear Factor-κB in Murine Hepatocellular Carcinomas

Nuclear factor-κB (NF-κB) plays an important role during liver neoplastic development through transcriptional regulation of prosurvival genes, which then counteract the death-inducing signals elicited by the host immune response. The c-Myc proto-oncogene is frequently deregulated in liver tumors. Fu...

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Veröffentlicht in:	Molecular cancer research 2005-07, Vol.3 (7), p.403-412
Hauptverfasser:	Cavin, Lakita G., Wang, Fang, Factor, Valentina M., Kaur, Swayamjot, Venkatraman, Manickam, Thorgeirsson, Snorri S., Arsura, Marcello
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Bcl-XL IKK liver cancer PI3K XIAP
Online-Zugang:	Volltext
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