Effects of apolipoprotein E on the human immunodeficiency virus protein tat in neuronal cultures and synaptosomes

Human immunodeficiency virus type 1 (HIV‐1)‐associated dementia is observed in 20–30% of patients with acquired immunodeficiency syndrome (AIDS). The ϵ4 allele of the apolipoprotein E (APOE) gene currently is thought to play a role as a risk factor for the development of HIV dementia. The HIV protei...

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Veröffentlicht in:	Journal of neuroscience research 2004-08, Vol.77 (4), p.532-539
Hauptverfasser:	Pocernich, Chava B., Sultana, Rukhsana, Hone, Eugene, Turchan, Jadwiga, Martins, Ralph N., Calabrese, Vittorio, Nath, Avindra, Butterfield, D. Allan
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Dementia Complex - genetics AIDS Dementia Complex - metabolism AIDS Dementia Complex - physiopathology Animals Antioxidants - metabolism Antioxidants - pharmacology ApoE3 ApoE4 Apolipoprotein E3 Apolipoprotein E4 Apolipoproteins E - genetics Apolipoproteins E - metabolism Apolipoproteins E - pharmacology Cell Membrane - drug effects Cell Membrane - metabolism Cells, Cultured Gene Products, tat - antagonists & inhibitors Gene Products, tat - toxicity Genetic Predisposition to Disease - genetics HIV dementia Human immunodeficiency virus 1 Humans Lipid Peroxidation - drug effects LRP receptor Metabolic Clearance Rate - genetics Mice Mice, Knockout Neurons - drug effects Neurons - metabolism Neuroprotective Agents - metabolism Neuroprotective Agents - pharmacology oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics Reactive Oxygen Species - metabolism Synaptosomes - metabolism Tat tat Gene Products, Human Immunodeficiency Virus
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