N-Acylthiadiazolines, a New Class of Liver X Receptor Agonists with Selectivity for LXRβ

We have identified a novel liver X receptor (LXR) agonist (2) that activates the LXRβ subtype with selectivity over LXRα. LXRβ selectivity was confirmed using macrophages derived from LXR mutant mice. Despite its selectivity and modest potency, the compound can induce APO-AI-dependent cholesterol ef...

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Veröffentlicht in:	Journal of medicinal chemistry 2007-08, Vol.50 (17), p.4255-4259
Hauptverfasser:	Molteni, Valentina, Li, Xiaolin, Nabakka, Juliet, Liang, Fang, Wityak, John, Koder, Alan, Vargas, Leo, Romeo, Russell, Mitro, Nico, Mak, Puiying A, Seidel, H. Martin, Haslam, Jennifer A, Chow, Donald, Tuntland, Tove, Spalding, Tracy A, Brock, Ansgar, Bradley, Michelle, Castrillo, Antonio, Tontonoz, Peter, Saez, Enrique
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Hormones. Endocrine system Medical sciences Pharmacology. Drug treatments
Online-Zugang:	Volltext
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