Evaluation of the safety of mixed tocopheryl phosphates (MTP)—A formulation of α-tocopheryl phosphate plus α-di-tocopheryl phosphate

The safety of a formulation of mixed tocopheryl phosphates, (MTP) was evaluated in a series of toxicological tests in vivo using rats, mice and rabbits and in vitro using bacterial and mammalian cell cultures. The tests conducted included an oral LD 50 study, three 28-day oral repeat-dose studies, t...

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Veröffentlicht in:	Food and chemical toxicology 2006-07, Vol.44 (7), p.916-932
Hauptverfasser:	Libinaki, R., Ogru, E., Gianello, R., Bolton, L., Geytenbeek, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	active ingredients acute toxicity alpha-tocopherol alpha-Tocopherol - administration & dosage alpha-Tocopherol - analogs & derivatives alpha-Tocopherol - chemistry alpha-Tocopherol - toxicity Animals Antioxidants - administration & dosage Antioxidants - toxicity Biological and medical sciences Blood Cell Count Blood Chemical Analysis Body Weight - drug effects Chromosome Aberrations - drug effects Dermatitis - pathology dietary exposure Dose-Response Relationship, Drug Escherichia coli esters Eye Diseases - chemically induced Female food additives genotoxicity Hypersensitivity - pathology Irritants Male Medical sciences Mice Mice, Inbred CBA mutagenicity Mutagenicity Tests Mutagens Organ Size - drug effects phosphates Rabbits Rats Rats, Wistar Safety safety testing Salmonella typhimurium skin irritation Tocopherol Tocopherol esters Tocopheryl phosphate toxicity testing Toxicology Vitamin E phosphate
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