Gastroenteropancreatic neuroendocrine neoplasms: selected pathology review and molecular updates
Gastroenteropancreatic (GEP) neuroendocrine neoplasms can be broadly separated into well‐ and poorly differentiated categories. Tumours within each category have similarities in morphology and immunophenotype, but vary in grade, behaviour, molecular signature and responses to therapy. The aetiology...
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| Veröffentlicht in: | Histopathology 2018-01, Vol.72 (1), p.153-167 |
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| creator | Chai, Siaw M Brown, Ian S Kumarasinghe, M Priyanthi |
| description | Gastroenteropancreatic (GEP) neuroendocrine neoplasms can be broadly separated into well‐ and poorly differentiated categories. Tumours within each category have similarities in morphology and immunophenotype, but vary in grade, behaviour, molecular signature and responses to therapy. The aetiology of these differences is multifactorial. Site of origin, mucosal milieu and hereditary influences are some of the currently known factors. Given these differences, staging and grading systems continue to evolve, and the most recent World Health Organization classification of pancreatic neuroendocrine neoplasms reflects this by introducing a grade 3 neuroendocrine tumour category for morphologically well‐differentiated tumours with an elevated Ki‐67 proliferation index and/or mitotic count. This review aims to highlight current classification guidelines with discussion of unique site‐specific features of selected GEP neuroendocrine neoplasms and an emphasis on practical issues related to daily reporting. |
| doi_str_mv | 10.1111/his.13367 |
| format | Article |
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Tumours within each category have similarities in morphology and immunophenotype, but vary in grade, behaviour, molecular signature and responses to therapy. The aetiology of these differences is multifactorial. Site of origin, mucosal milieu and hereditary influences are some of the currently known factors. Given these differences, staging and grading systems continue to evolve, and the most recent World Health Organization classification of pancreatic neuroendocrine neoplasms reflects this by introducing a grade 3 neuroendocrine tumour category for morphologically well‐differentiated tumours with an elevated Ki‐67 proliferation index and/or mitotic count. 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Tumours within each category have similarities in morphology and immunophenotype, but vary in grade, behaviour, molecular signature and responses to therapy. The aetiology of these differences is multifactorial. Site of origin, mucosal milieu and hereditary influences are some of the currently known factors. Given these differences, staging and grading systems continue to evolve, and the most recent World Health Organization classification of pancreatic neuroendocrine neoplasms reflects this by introducing a grade 3 neuroendocrine tumour category for morphologically well‐differentiated tumours with an elevated Ki‐67 proliferation index and/or mitotic count. This review aims to highlight current classification guidelines with discussion of unique site‐specific features of selected GEP neuroendocrine neoplasms and an emphasis on practical issues related to daily reporting.</description><subject>carcinoid tumor</subject><subject>Classification</subject><subject>Gastrointestinal Neoplasms - pathology</subject><subject>Humans</subject><subject>Ki‐67 antigen</subject><subject>Mucosa</subject><subject>neuroendocrine carcinoma</subject><subject>Neuroendocrine tumors</subject><subject>Neuroendocrine Tumors - pathology</subject><subject>neuroendocrine tumours</subject><subject>Pancreas</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Tumors</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFOwzAMhiMEYmNw4AVQJS5w6JY0TdJyQxNskyZxAM4lTT3WKW1K0jLt7cno4ICEL5btz7-tH6FLgsfEx2RdujGhlIsjNCSUszBiLD1GQ0xxGmLCxQCdObfBmAgaRadoEKURTTFNhuhtJl1rDdQtWNPIWlmQbamCGrp9tzDKljX40jRausrdBQ40qBaKoJHt2mjzvgssfJawDWRdBJXx005LG3RNIVtw5-hkJbWDi0MeodfHh5fpPFw-zRbT-2WoYpKKUOY4jldRnCQ5k0JGKk1BJZwrrjDDALmgBVEQkaIQMfiVHOiKccYSSZWQnI7QTa_bWPPRgWuzqnQKtJb-985l_oggCU848ej1H3RjOlv77_YUp5RRzDx121PKGucsrLLGlpW0u4zgbG975m3Pvm337NVBscsrKH7JH589MOmBbalh979SNl8895JfoquN0w</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Chai, Siaw M</creator><creator>Brown, Ian S</creator><creator>Kumarasinghe, M Priyanthi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9272-6700</orcidid></search><sort><creationdate>201801</creationdate><title>Gastroenteropancreatic neuroendocrine neoplasms: selected pathology review and molecular updates</title><author>Chai, Siaw M ; Brown, Ian S ; Kumarasinghe, M Priyanthi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4197-ab044f2488b5a7a2c99ec866c6c050eeb73d1ce21dd74e419be3f56558a3c7a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>carcinoid tumor</topic><topic>Classification</topic><topic>Gastrointestinal Neoplasms - pathology</topic><topic>Humans</topic><topic>Ki‐67 antigen</topic><topic>Mucosa</topic><topic>neuroendocrine carcinoma</topic><topic>Neuroendocrine tumors</topic><topic>Neuroendocrine Tumors - pathology</topic><topic>neuroendocrine tumours</topic><topic>Pancreas</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chai, Siaw M</creatorcontrib><creatorcontrib>Brown, Ian S</creatorcontrib><creatorcontrib>Kumarasinghe, M Priyanthi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chai, Siaw M</au><au>Brown, Ian S</au><au>Kumarasinghe, M Priyanthi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastroenteropancreatic neuroendocrine neoplasms: selected pathology review and molecular updates</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2018-01</date><risdate>2018</risdate><volume>72</volume><issue>1</issue><spage>153</spage><epage>167</epage><pages>153-167</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Gastroenteropancreatic (GEP) neuroendocrine neoplasms can be broadly separated into well‐ and poorly differentiated categories. 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| ispartof | Histopathology, 2018-01, Vol.72 (1), p.153-167 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | carcinoid tumor Classification Gastrointestinal Neoplasms - pathology Humans Ki‐67 antigen Mucosa neuroendocrine carcinoma Neuroendocrine tumors Neuroendocrine Tumors - pathology neuroendocrine tumours Pancreas Pancreatic Neoplasms - pathology Tumors |
| title | Gastroenteropancreatic neuroendocrine neoplasms: selected pathology review and molecular updates |
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