Lethal toxin of Bacillus anthracis causes apoptosis of macrophages

Lethal toxin is a major anthrax virulence factor, causing the rapid death of experimental animals. Lethal toxin can enter most cell types, but only certain macrophages and cell lines are susceptible to toxin-mediated cytolysis. We have shown that in murine RAW 264.7 cells, sublytic amounts of lethal...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2002-04, Vol.293 (1), p.349-355
Hauptverfasser:	Popov, Serguei G, Villasmil, Rafael, Bernardi, Jessica, Grene, Edith, Cardwell, Jennifer, Wu, Aiguo, Alibek, Darya, Bailey, Charles, Alibek, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthrax Antigens, Bacterial Apoptosis Apoptosis - drug effects Bacillus anthracis Bacterial Toxins Bactericidal activity Carrier Proteins - antagonists & inhibitors Carrier Proteins - toxicity Caspase 3 Caspase 8 Caspase 9 Caspase Inhibitors Cell Line Cysteine Proteinase Inhibitors - pharmacology Lethal toxin Macrophages Macrophages - cytology Macrophages - drug effects Macrophages - physiology Mice
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!