Mutant Viral Polymerase in the Transition of Virus to Error Catastrophe Identifies a Critical Site for RNA Binding

A foot-and-mouth disease virus (FMDV) polymerase (3D) with amino acid replacements G118D, V239M and G373D (triple DMD mutant) was obtained from a molecular clone derived from a virus population treated with ribavirin, in the transition to error catastrophe (virus extinction through lethal mutagenesi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular biology 2005-11, Vol.353 (5), p.1021-1032
Hauptverfasser:	Arias, Armando, Agudo, Rubén, Ferrer-Orta, Cristina, Pérez-Luque, Rosa, Airaksinen, Antero, Brocchi, Emiliana, Domingo, Esteban, Verdaguer, Nuria, Escarmís, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cloning, Molecular Escherichia coli Escherichia coli - genetics Foot-and-mouth disease virus Foot-and-Mouth Disease Virus - enzymology Foot-and-Mouth Disease Virus - genetics Kinetics lethal mutagenesis Mutagenesis, Site-Directed Mutation, Missense reversion RNA Replicase - genetics RNA Replicase - metabolism RNA, Viral - metabolism RNA-dependent RNA polymerase Templates, Genetic viral quasispecies
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!