Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib

Most cancers preserve functional retinoblastoma (Rb) and may, therefore, respond to inhibition of D-cyclin-dependent Rb kinases, CDK4 and CDK6. To date, CDK4/6 inhibitors have shown promising clinical activity in breast cancer and lymphomas, but it is not clear which additional Rb-positive cancers m...

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Veröffentlicht in:	Cancer cell 2017-12, Vol.32 (6), p.761-776.e6
Hauptverfasser:	Gong, Xueqian, Litchfield, Lacey M., Webster, Yue, Chio, Li-Chun, Wong, Swee Seong, Stewart, Trent R., Dowless, Michele, Dempsey, Jack, Zeng, Yi, Torres, Raquel, Boehnke, Karsten, Mur, Cecilia, Marugán, Carlos, Baquero, Carmen, Yu, Chunping, Bray, Steven M., Wulur, Isabella H., Bi, Chen, Chu, Shaoyou, Qian, Hui-Rong, Iversen, Philip W., Merzoug, Farhana F., Ye, Xiang S., Reinhard, Christoph, De Dios, Alfonso, Du, Jian, Caldwell, Charles W., Lallena, María José, Beckmann, Richard P., Buchanan, Sean G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyridines - pharmacology Animals Antineoplastic Agents - pharmacology Benzimidazoles - pharmacology CCND1 CCND2 CCND3 CDK2 CDKN2A Cell Proliferation - drug effects Clinical Trials, Phase I as Topic Cyclin D - genetics Cyclin D - metabolism Cyclin-Dependent Kinase 4 - antagonists & inhibitors Cyclin-Dependent Kinase 6 - antagonists & inhibitors Female Humans Mice Mice, Inbred BALB C Mice, Nude Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Xenograft Model Antitumor Assays
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