Direct and Enantioselective Synthesis of N−H‐Free 1,5‐Benzodiazepin‐2‐ones by an N‐Heterocyclic Carbene Catalyzed [3+4] Annulation Reaction

An NHC‐catalyzed formal [3+4] annulation of α,β‐unsaturated acylazoliums with protecting‐group‐free aryl 1,2‐diamines was developed for a direct and highly enantioselective synthesis of 4‐aryl N−H‐free 1,5‐benzodiazepin‐2‐ones. This methodology offers an efficient and rapid access to a wide range of...

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Veröffentlicht in:	Chemistry : a European journal 2018-02, Vol.24 (9), p.2103-2108
Hauptverfasser:	Fang, Chao, Cao, Jing, Sun, Kewen, Zhu, Jindong, Lu, Tao, Du, Ding
Format:	Artikel
Sprache:	eng
Schlagworte:	annulation Aromatic compounds asymmetric synthesis benzodiazepinone carbenes Chemical reactions Chemical synthesis Chemistry Diamines Enantiomers Organic chemistry unsaturated acylazolium
Online-Zugang:	Volltext
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