Association of gene polymorphisms of pattern‐recognition receptor signaling pathway with the risk and severity of hand, foot, and mouth disease caused by enterovirus 71 in Chinese Han population
Hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) presents with a wide variety of clinical manifestations. Host immune response is a factor that influences disease susceptibility and severity. We investigated the potential association of gene polymorphisms in the pattern recogniti...
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| Veröffentlicht in: | Journal of medical virology 2018-04, Vol.90 (4), p.692-698 |
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| creator | Li, Ya‐Ping Li, Mei Jia, Xiao‐Li Deng, Hui‐Ling Wang, Wen‐Jun Wu, Feng‐Ping Wang, Jun Dang, Shuang‐Suo |
| description | Hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) presents with a wide variety of clinical manifestations. Host immune response is a factor that influences disease susceptibility and severity. We investigated the potential association of gene polymorphisms in the pattern recognition receptor (PRR) pathway with the risk and severity of EV71 infection. A total of 180 EV71 HFMD cases (108 severe case; 72 mild cases) were enrolled. A group of 201 sex‐ and age‐matched children was included as a control. All subjects were genotyped for the most common single‐nucleotide polymorphisms (SNPs) in the PRR and the PRR signaling pathway using the SNPscan multiple SNP typing method. Binary logistic regression analysis revealed statistically significant differences in polymorphism of RIG‐1 between patients and controls (rs3739674 G vs C: OR = 1.502, 95%CI: 1.120‐2.014; rs9695310 G vs C: OR = 1.782, 95%CI: 1.312‐2.419). Polymorphisms of RIG‐1 rs3739674 (G vs C: OR = 2.047, 95%CI: 1.307‐3.205) and TLR3 rs5743305 (A vs T: OR = 0.346, 95%CI: 0.212‐0.566) were found to be associated with disease severity. The results indicated that RIG‐1 (rs3739674 and rs9695310) polymorphisms are associated with an increased risk of EV71‐induced HFMD in Chinese children, whereas RIG‐1 rs3739674 and TLR3 rs5743305 polymorphisms are associated with disease severity. These findings support an important role of innate immune mechanism in EV71 infection. |
| doi_str_mv | 10.1002/jmv.25000 |
| format | Article |
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Host immune response is a factor that influences disease susceptibility and severity. We investigated the potential association of gene polymorphisms in the pattern recognition receptor (PRR) pathway with the risk and severity of EV71 infection. A total of 180 EV71 HFMD cases (108 severe case; 72 mild cases) were enrolled. A group of 201 sex‐ and age‐matched children was included as a control. All subjects were genotyped for the most common single‐nucleotide polymorphisms (SNPs) in the PRR and the PRR signaling pathway using the SNPscan multiple SNP typing method. Binary logistic regression analysis revealed statistically significant differences in polymorphism of RIG‐1 between patients and controls (rs3739674 G vs C: OR = 1.502, 95%CI: 1.120‐2.014; rs9695310 G vs C: OR = 1.782, 95%CI: 1.312‐2.419). Polymorphisms of RIG‐1 rs3739674 (G vs C: OR = 2.047, 95%CI: 1.307‐3.205) and TLR3 rs5743305 (A vs T: OR = 0.346, 95%CI: 0.212‐0.566) were found to be associated with disease severity. The results indicated that RIG‐1 (rs3739674 and rs9695310) polymorphisms are associated with an increased risk of EV71‐induced HFMD in Chinese children, whereas RIG‐1 rs3739674 and TLR3 rs5743305 polymorphisms are associated with disease severity. These findings support an important role of innate immune mechanism in EV71 infection.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.25000</identifier><identifier>PMID: 29235129</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Asian Continental Ancestry Group ; Child ; Child, Preschool ; Children ; China ; enterovirus 71 ; Enterovirus A, Human - immunology ; Enteroviruses ; Female ; gene polymorphism ; Genetic Predisposition to Disease ; Genotyping Techniques ; Hand, Foot and Mouth Disease - genetics ; Hand, Foot and Mouth Disease - pathology ; Hand-foot-and-mouth disease ; Health risks ; Humans ; Immune response ; Immune system ; Infant ; Infections ; Male ; Pattern recognition ; Pattern recognition receptors ; Polymorphism ; Polymorphism, Single Nucleotide ; Receptors, Pattern Recognition - genetics ; Receptors, Retinoic Acid - genetics ; Regression analysis ; Risk ; Risk Assessment ; risk factors ; Severity of Illness Index ; Signal Transduction ; Signaling ; Single-nucleotide polymorphism ; Statistical analysis ; TLR3 protein ; Toll-like receptors ; Virology</subject><ispartof>Journal of medical virology, 2018-04, Vol.90 (4), p.692-698</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-8119a5ca59369340d39eca342da389a75ac05de823ffc1f0a74a0809524c0b923</citedby><cites>FETCH-LOGICAL-c3530-8119a5ca59369340d39eca342da389a75ac05de823ffc1f0a74a0809524c0b923</cites><orcidid>0000-0002-9257-5711 ; 0000-0002-7532-8647</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.25000$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.25000$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29235129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ya‐Ping</creatorcontrib><creatorcontrib>Li, Mei</creatorcontrib><creatorcontrib>Jia, Xiao‐Li</creatorcontrib><creatorcontrib>Deng, Hui‐Ling</creatorcontrib><creatorcontrib>Wang, Wen‐Jun</creatorcontrib><creatorcontrib>Wu, Feng‐Ping</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Dang, Shuang‐Suo</creatorcontrib><title>Association of gene polymorphisms of pattern‐recognition receptor signaling pathway with the risk and severity of hand, foot, and mouth disease caused by enterovirus 71 in Chinese Han population</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>Hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) presents with a wide variety of clinical manifestations. Host immune response is a factor that influences disease susceptibility and severity. We investigated the potential association of gene polymorphisms in the pattern recognition receptor (PRR) pathway with the risk and severity of EV71 infection. A total of 180 EV71 HFMD cases (108 severe case; 72 mild cases) were enrolled. A group of 201 sex‐ and age‐matched children was included as a control. All subjects were genotyped for the most common single‐nucleotide polymorphisms (SNPs) in the PRR and the PRR signaling pathway using the SNPscan multiple SNP typing method. Binary logistic regression analysis revealed statistically significant differences in polymorphism of RIG‐1 between patients and controls (rs3739674 G vs C: OR = 1.502, 95%CI: 1.120‐2.014; rs9695310 G vs C: OR = 1.782, 95%CI: 1.312‐2.419). Polymorphisms of RIG‐1 rs3739674 (G vs C: OR = 2.047, 95%CI: 1.307‐3.205) and TLR3 rs5743305 (A vs T: OR = 0.346, 95%CI: 0.212‐0.566) were found to be associated with disease severity. The results indicated that RIG‐1 (rs3739674 and rs9695310) polymorphisms are associated with an increased risk of EV71‐induced HFMD in Chinese children, whereas RIG‐1 rs3739674 and TLR3 rs5743305 polymorphisms are associated with disease severity. These findings support an important role of innate immune mechanism in EV71 infection.</description><subject>Asian Continental Ancestry Group</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>China</subject><subject>enterovirus 71</subject><subject>Enterovirus A, Human - immunology</subject><subject>Enteroviruses</subject><subject>Female</subject><subject>gene polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotyping Techniques</subject><subject>Hand, Foot and Mouth Disease - genetics</subject><subject>Hand, Foot and Mouth Disease - pathology</subject><subject>Hand-foot-and-mouth disease</subject><subject>Health risks</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Infant</subject><subject>Infections</subject><subject>Male</subject><subject>Pattern recognition</subject><subject>Pattern recognition receptors</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, Pattern Recognition - genetics</subject><subject>Receptors, Retinoic Acid - genetics</subject><subject>Regression analysis</subject><subject>Risk</subject><subject>Risk Assessment</subject><subject>risk factors</subject><subject>Severity of Illness Index</subject><subject>Signal Transduction</subject><subject>Signaling</subject><subject>Single-nucleotide polymorphism</subject><subject>Statistical analysis</subject><subject>TLR3 protein</subject><subject>Toll-like receptors</subject><subject>Virology</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10cFu1DAQBmALgehSOPACyBKXIjXt2ImT-FitgIKKuADXyOtMNl4SO9jJrnLjEXgonoQnwdktHJA42Rp_-j2aIeQ5gysGwK93_f6KCwB4QFYMZJ5IKNhDsgKW5UmeM3FGnoSwi6CUnD8mZ1zyVDAuV-TnTQhOGzUaZ6lr6BYt0sF1c-_80JrQh6U6qHFEb399_-FRu601Rx7vOIzO02C2VnXGbhfYHtRMD2Zs6dgi9SZ8pcrWNOAevRnnJa6NhUvaODdeHt96N0Vem4AqINVqCljTzUzRxl_d3vgp0IJRY-m6NRajuVU2djlM3bHxp-RRo7qAz-7Pc_L5zetP69vk7uPbd-ubu0SnIoWkZEwqoZWQaS7TDOpUolZpxmuVllIVQmkQNZY8bRrNGlBFpqAEKXimYRNHdk4uTrmDd98mDGPVm6Cx65RFN4WKySLPMp4BRPryH7pzk49TWpQUeUwts6henZT2LgSPTTV40ys_VwyqZbVVXG11XG20L-4Tp02P9V_5Z5cRXJ_AwXQ4_z-pev_hyynyN9Dqsbk</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Li, Ya‐Ping</creator><creator>Li, Mei</creator><creator>Jia, Xiao‐Li</creator><creator>Deng, Hui‐Ling</creator><creator>Wang, Wen‐Jun</creator><creator>Wu, Feng‐Ping</creator><creator>Wang, Jun</creator><creator>Dang, Shuang‐Suo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9257-5711</orcidid><orcidid>https://orcid.org/0000-0002-7532-8647</orcidid></search><sort><creationdate>201804</creationdate><title>Association of gene polymorphisms of pattern‐recognition receptor signaling pathway with the risk and severity of hand, foot, and mouth disease caused by enterovirus 71 in Chinese Han population</title><author>Li, Ya‐Ping ; Li, Mei ; Jia, Xiao‐Li ; Deng, Hui‐Ling ; Wang, Wen‐Jun ; Wu, Feng‐Ping ; Wang, Jun ; Dang, Shuang‐Suo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-8119a5ca59369340d39eca342da389a75ac05de823ffc1f0a74a0809524c0b923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Asian Continental Ancestry Group</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>China</topic><topic>enterovirus 71</topic><topic>Enterovirus A, Human - immunology</topic><topic>Enteroviruses</topic><topic>Female</topic><topic>gene polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotyping Techniques</topic><topic>Hand, Foot and Mouth Disease - genetics</topic><topic>Hand, Foot and Mouth Disease - pathology</topic><topic>Hand-foot-and-mouth disease</topic><topic>Health risks</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Infant</topic><topic>Infections</topic><topic>Male</topic><topic>Pattern recognition</topic><topic>Pattern recognition receptors</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, Pattern Recognition - genetics</topic><topic>Receptors, Retinoic Acid - genetics</topic><topic>Regression analysis</topic><topic>Risk</topic><topic>Risk Assessment</topic><topic>risk factors</topic><topic>Severity of Illness Index</topic><topic>Signal Transduction</topic><topic>Signaling</topic><topic>Single-nucleotide polymorphism</topic><topic>Statistical analysis</topic><topic>TLR3 protein</topic><topic>Toll-like receptors</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ya‐Ping</creatorcontrib><creatorcontrib>Li, Mei</creatorcontrib><creatorcontrib>Jia, Xiao‐Li</creatorcontrib><creatorcontrib>Deng, Hui‐Ling</creatorcontrib><creatorcontrib>Wang, Wen‐Jun</creatorcontrib><creatorcontrib>Wu, Feng‐Ping</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Dang, Shuang‐Suo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ya‐Ping</au><au>Li, Mei</au><au>Jia, Xiao‐Li</au><au>Deng, Hui‐Ling</au><au>Wang, Wen‐Jun</au><au>Wu, Feng‐Ping</au><au>Wang, Jun</au><au>Dang, Shuang‐Suo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of gene polymorphisms of pattern‐recognition receptor signaling pathway with the risk and severity of hand, foot, and mouth disease caused by enterovirus 71 in Chinese Han population</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2018-04</date><risdate>2018</risdate><volume>90</volume><issue>4</issue><spage>692</spage><epage>698</epage><pages>692-698</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>Hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) presents with a wide variety of clinical manifestations. Host immune response is a factor that influences disease susceptibility and severity. We investigated the potential association of gene polymorphisms in the pattern recognition receptor (PRR) pathway with the risk and severity of EV71 infection. A total of 180 EV71 HFMD cases (108 severe case; 72 mild cases) were enrolled. A group of 201 sex‐ and age‐matched children was included as a control. All subjects were genotyped for the most common single‐nucleotide polymorphisms (SNPs) in the PRR and the PRR signaling pathway using the SNPscan multiple SNP typing method. Binary logistic regression analysis revealed statistically significant differences in polymorphism of RIG‐1 between patients and controls (rs3739674 G vs C: OR = 1.502, 95%CI: 1.120‐2.014; rs9695310 G vs C: OR = 1.782, 95%CI: 1.312‐2.419). Polymorphisms of RIG‐1 rs3739674 (G vs C: OR = 2.047, 95%CI: 1.307‐3.205) and TLR3 rs5743305 (A vs T: OR = 0.346, 95%CI: 0.212‐0.566) were found to be associated with disease severity. The results indicated that RIG‐1 (rs3739674 and rs9695310) polymorphisms are associated with an increased risk of EV71‐induced HFMD in Chinese children, whereas RIG‐1 rs3739674 and TLR3 rs5743305 polymorphisms are associated with disease severity. These findings support an important role of innate immune mechanism in EV71 infection.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29235129</pmid><doi>10.1002/jmv.25000</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9257-5711</orcidid><orcidid>https://orcid.org/0000-0002-7532-8647</orcidid></addata></record> |
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| subjects | Asian Continental Ancestry Group Child Child, Preschool Children China enterovirus 71 Enterovirus A, Human - immunology Enteroviruses Female gene polymorphism Genetic Predisposition to Disease Genotyping Techniques Hand, Foot and Mouth Disease - genetics Hand, Foot and Mouth Disease - pathology Hand-foot-and-mouth disease Health risks Humans Immune response Immune system Infant Infections Male Pattern recognition Pattern recognition receptors Polymorphism Polymorphism, Single Nucleotide Receptors, Pattern Recognition - genetics Receptors, Retinoic Acid - genetics Regression analysis Risk Risk Assessment risk factors Severity of Illness Index Signal Transduction Signaling Single-nucleotide polymorphism Statistical analysis TLR3 protein Toll-like receptors Virology |
| title | Association of gene polymorphisms of pattern‐recognition receptor signaling pathway with the risk and severity of hand, foot, and mouth disease caused by enterovirus 71 in Chinese Han population |
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