Remote sampling mass spectrometry for dry samples: Sheath‐flow probe electrospray ionization (PESI) using a gel‐loading tip inserted with an acupuncture needle
Rationale Probe electrospray ionization (PESI) is only applicable to liquid or wet samples. In this study, a sheath‐flow PESI method for remote sampling mass spectrometry that can be applied to dry samples was developed. Methods An acupuncture needle (0.12 mm outer diameter, 700 nm tip diameter) was...
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| Veröffentlicht in: | Rapid communications in mass spectrometry 2018-03, Vol.32 (5), p.407-413 |
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| creator | Usmanov, Dilshadbek T. Ashurov, Khatam B. Ninomiya, Satoshi Hiraoka, Kenzo Wada, Hiroshi Nakano, Hiroshi Matsumura, Masaya Sanada‐Morimura, Sachiyo Nonami, Hiroshi |
| description | Rationale
Probe electrospray ionization (PESI) is only applicable to liquid or wet samples. In this study, a sheath‐flow PESI method for remote sampling mass spectrometry that can be applied to dry samples was developed.
Methods
An acupuncture needle (0.12 mm outer diameter, 700 nm tip diameter) was inserted into a gel‐loading tip with a 0.1 mm protrusion out of the tip. Analytes were extracted by filling the latter tip with solvent and softly touching the sample surface for a short time ( |
| doi_str_mv | 10.1002/rcm.8045 |
| format | Article |
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Probe electrospray ionization (PESI) is only applicable to liquid or wet samples. In this study, a sheath‐flow PESI method for remote sampling mass spectrometry that can be applied to dry samples was developed.
Methods
An acupuncture needle (0.12 mm outer diameter, 700 nm tip diameter) was inserted into a gel‐loading tip with a 0.1 mm protrusion out of the tip. Analytes were extracted by filling the latter tip with solvent and softly touching the sample surface for a short time (<1 s). A high voltage was applied to the acupuncture needle, and mass spectra of analytes were obtained by self‐aspirating electrospray.
Results
Dry samples, such as lines of ballpoint pen ink on paper, pharmaceutical tablets, instant coffee, brown rice, and narcotics, gave strong ion signals. The sample carryover was negligible. The sequential electrospray was observed to be similar to conventional PESI. The limits of detection (LODs) for morphine and rhodamine B were found to be of the order of picograms.
Conclusions
Because of its simplicity and versatility, sheath‐flow PESI is a promising technique for on‐site and nondestructive profile analysis of dry samples with bulky and complicated shapes, with a spatial resolution of ~0.3 mm.</description><identifier>ISSN: 0951-4198</identifier><identifier>EISSN: 1097-0231</identifier><identifier>DOI: 10.1002/rcm.8045</identifier><identifier>PMID: 29235697</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Acupuncture ; Analytical chemistry ; Electrospraying ; Instant coffee ; Ionization ; Ions ; Mass spectra ; Mass spectrometry ; Morphine ; Narcotics ; Nondestructive testing ; Rhodamine ; Sampling methods ; Scientific imaging ; Spatial resolution ; Spectroscopy ; Tablets</subject><ispartof>Rapid communications in mass spectrometry, 2018-03, Vol.32 (5), p.407-413</ispartof><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3495-41591197bd37d34f3da705607e5c644ef9413e68aa7de1686e9258ceac48e4bb3</citedby><cites>FETCH-LOGICAL-c3495-41591197bd37d34f3da705607e5c644ef9413e68aa7de1686e9258ceac48e4bb3</cites><orcidid>0000-0001-5425-0716 ; 0000-0003-0734-8096</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Frcm.8045$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Frcm.8045$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29235697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Usmanov, Dilshadbek T.</creatorcontrib><creatorcontrib>Ashurov, Khatam B.</creatorcontrib><creatorcontrib>Ninomiya, Satoshi</creatorcontrib><creatorcontrib>Hiraoka, Kenzo</creatorcontrib><creatorcontrib>Wada, Hiroshi</creatorcontrib><creatorcontrib>Nakano, Hiroshi</creatorcontrib><creatorcontrib>Matsumura, Masaya</creatorcontrib><creatorcontrib>Sanada‐Morimura, Sachiyo</creatorcontrib><creatorcontrib>Nonami, Hiroshi</creatorcontrib><title>Remote sampling mass spectrometry for dry samples: Sheath‐flow probe electrospray ionization (PESI) using a gel‐loading tip inserted with an acupuncture needle</title><title>Rapid communications in mass spectrometry</title><addtitle>Rapid Commun Mass Spectrom</addtitle><description>Rationale
Probe electrospray ionization (PESI) is only applicable to liquid or wet samples. In this study, a sheath‐flow PESI method for remote sampling mass spectrometry that can be applied to dry samples was developed.
Methods
An acupuncture needle (0.12 mm outer diameter, 700 nm tip diameter) was inserted into a gel‐loading tip with a 0.1 mm protrusion out of the tip. Analytes were extracted by filling the latter tip with solvent and softly touching the sample surface for a short time (<1 s). A high voltage was applied to the acupuncture needle, and mass spectra of analytes were obtained by self‐aspirating electrospray.
Results
Dry samples, such as lines of ballpoint pen ink on paper, pharmaceutical tablets, instant coffee, brown rice, and narcotics, gave strong ion signals. The sample carryover was negligible. The sequential electrospray was observed to be similar to conventional PESI. The limits of detection (LODs) for morphine and rhodamine B were found to be of the order of picograms.
Conclusions
Because of its simplicity and versatility, sheath‐flow PESI is a promising technique for on‐site and nondestructive profile analysis of dry samples with bulky and complicated shapes, with a spatial resolution of ~0.3 mm.</description><subject>Acupuncture</subject><subject>Analytical chemistry</subject><subject>Electrospraying</subject><subject>Instant coffee</subject><subject>Ionization</subject><subject>Ions</subject><subject>Mass spectra</subject><subject>Mass spectrometry</subject><subject>Morphine</subject><subject>Narcotics</subject><subject>Nondestructive testing</subject><subject>Rhodamine</subject><subject>Sampling methods</subject><subject>Scientific imaging</subject><subject>Spatial resolution</subject><subject>Spectroscopy</subject><subject>Tablets</subject><issn>0951-4198</issn><issn>1097-0231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kdFqFDEUhoModq2CTyABb-rF1GSSzEy8k6VqoaK0eh0yyZluSmYyJhmW9cpH8B18M5_E7LYqCF79BL7zkXN-hJ5SckoJqV9GM552hIt7aEWJbCtSM3ofrYgUtOJUdkfoUUo3hFAqavIQHdWyZqKR7Qr9uIQxZMBJj7N30zUedUo4zWByDCPkuMNDiNiWPCCQXuGrDei8-fnt--DDFs8x9IDBHybSHPUOuzC5rzqXwCcfz67OX-Al7d0aX4Mvcz5ou39nN2M3JYgZLN66vMF6wtos8zKZvETAE4D18Bg9GLRP8OQuj9HnN2ef1u-qiw9vz9evLyrDuBRlUSEplW1vWWsZH5jVLRENaUGYhnMYJKcMmk7r1gJtugZkLToD2vAOeN-zY3Ry6y0rfVkgZTW6ZMB7PUFYkiru4qlpxwr6_B_0JixxKr9TdSmEcNI1_K_QlMukCIOaoxt13ClK1L44VYpT--IK-uxOuPQj2D_g76YKUN0CW-dh91-Ruly_Pwh_ARwppds</recordid><startdate>20180315</startdate><enddate>20180315</enddate><creator>Usmanov, Dilshadbek T.</creator><creator>Ashurov, Khatam B.</creator><creator>Ninomiya, Satoshi</creator><creator>Hiraoka, Kenzo</creator><creator>Wada, Hiroshi</creator><creator>Nakano, Hiroshi</creator><creator>Matsumura, Masaya</creator><creator>Sanada‐Morimura, Sachiyo</creator><creator>Nonami, Hiroshi</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>JQ2</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5425-0716</orcidid><orcidid>https://orcid.org/0000-0003-0734-8096</orcidid></search><sort><creationdate>20180315</creationdate><title>Remote sampling mass spectrometry for dry samples: Sheath‐flow probe electrospray ionization (PESI) using a gel‐loading tip inserted with an acupuncture needle</title><author>Usmanov, Dilshadbek T. ; Ashurov, Khatam B. ; Ninomiya, Satoshi ; Hiraoka, Kenzo ; Wada, Hiroshi ; Nakano, Hiroshi ; Matsumura, Masaya ; Sanada‐Morimura, Sachiyo ; Nonami, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3495-41591197bd37d34f3da705607e5c644ef9413e68aa7de1686e9258ceac48e4bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acupuncture</topic><topic>Analytical chemistry</topic><topic>Electrospraying</topic><topic>Instant coffee</topic><topic>Ionization</topic><topic>Ions</topic><topic>Mass spectra</topic><topic>Mass spectrometry</topic><topic>Morphine</topic><topic>Narcotics</topic><topic>Nondestructive testing</topic><topic>Rhodamine</topic><topic>Sampling methods</topic><topic>Scientific imaging</topic><topic>Spatial resolution</topic><topic>Spectroscopy</topic><topic>Tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Usmanov, Dilshadbek T.</creatorcontrib><creatorcontrib>Ashurov, Khatam B.</creatorcontrib><creatorcontrib>Ninomiya, Satoshi</creatorcontrib><creatorcontrib>Hiraoka, Kenzo</creatorcontrib><creatorcontrib>Wada, Hiroshi</creatorcontrib><creatorcontrib>Nakano, Hiroshi</creatorcontrib><creatorcontrib>Matsumura, Masaya</creatorcontrib><creatorcontrib>Sanada‐Morimura, Sachiyo</creatorcontrib><creatorcontrib>Nonami, Hiroshi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Rapid communications in mass spectrometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Usmanov, Dilshadbek T.</au><au>Ashurov, Khatam B.</au><au>Ninomiya, Satoshi</au><au>Hiraoka, Kenzo</au><au>Wada, Hiroshi</au><au>Nakano, Hiroshi</au><au>Matsumura, Masaya</au><au>Sanada‐Morimura, Sachiyo</au><au>Nonami, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Remote sampling mass spectrometry for dry samples: Sheath‐flow probe electrospray ionization (PESI) using a gel‐loading tip inserted with an acupuncture needle</atitle><jtitle>Rapid communications in mass spectrometry</jtitle><addtitle>Rapid Commun Mass Spectrom</addtitle><date>2018-03-15</date><risdate>2018</risdate><volume>32</volume><issue>5</issue><spage>407</spage><epage>413</epage><pages>407-413</pages><issn>0951-4198</issn><eissn>1097-0231</eissn><abstract>Rationale
Probe electrospray ionization (PESI) is only applicable to liquid or wet samples. In this study, a sheath‐flow PESI method for remote sampling mass spectrometry that can be applied to dry samples was developed.
Methods
An acupuncture needle (0.12 mm outer diameter, 700 nm tip diameter) was inserted into a gel‐loading tip with a 0.1 mm protrusion out of the tip. Analytes were extracted by filling the latter tip with solvent and softly touching the sample surface for a short time (<1 s). A high voltage was applied to the acupuncture needle, and mass spectra of analytes were obtained by self‐aspirating electrospray.
Results
Dry samples, such as lines of ballpoint pen ink on paper, pharmaceutical tablets, instant coffee, brown rice, and narcotics, gave strong ion signals. The sample carryover was negligible. The sequential electrospray was observed to be similar to conventional PESI. The limits of detection (LODs) for morphine and rhodamine B were found to be of the order of picograms.
Conclusions
Because of its simplicity and versatility, sheath‐flow PESI is a promising technique for on‐site and nondestructive profile analysis of dry samples with bulky and complicated shapes, with a spatial resolution of ~0.3 mm.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29235697</pmid><doi>10.1002/rcm.8045</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5425-0716</orcidid><orcidid>https://orcid.org/0000-0003-0734-8096</orcidid></addata></record> |
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| subjects | Acupuncture Analytical chemistry Electrospraying Instant coffee Ionization Ions Mass spectra Mass spectrometry Morphine Narcotics Nondestructive testing Rhodamine Sampling methods Scientific imaging Spatial resolution Spectroscopy Tablets |
| title | Remote sampling mass spectrometry for dry samples: Sheath‐flow probe electrospray ionization (PESI) using a gel‐loading tip inserted with an acupuncture needle |
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