Progressive Development of Aberrant Smooth Muscle Cell Phenotype in Abdominal Aortic Aneurysm Disease

Abdominal aortic aneurysm (AAA) is a silent, progressive disease with a high mortality and an increasing prevalence with aging. Smooth muscle cell (SMC) dysfunction contributes to gradual dilatation and eventual rupture of the aorta. Here we studied phenotypic characteristics in SMC cultured from en...

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Veröffentlicht in:	Journal of vascular research 2018-01, Vol.55 (1), p.35-46
Hauptverfasser:	Riches, Kirsten, Clark, Emily, Helliwell, Rebecca J., Angelini, Timothy G., Hemmings, Karen E., Bailey, Marc A., Bridge, Katherine I., Scott, D. Julian A., Porter, Karen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal aortic aneurysm Analysis Aneurysm Angiotensin II Animals Aorta, Abdominal - metabolism Aorta, Abdominal - pathology Aortic aneurysm Aortic Aneurysm, Abdominal - complications Aortic Aneurysm, Abdominal - metabolism Aortic Aneurysm, Abdominal - pathology Aortic Rupture - etiology Aortic Rupture - metabolism Aortic Rupture - pathology Cell Differentiation Cell Shape Cells, Cultured Cellular Senescence Dilatation, Pathologic Disease Progression DNA DNA Damage Genetic aspects Health aspects Histones - metabolism Humans MicroRNAs - genetics MicroRNAs - metabolism Muscle, Smooth - metabolism Muscle, Smooth - pathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Phenotype Research Paper Sirtuin 1 - metabolism Smooth muscle Sus scrofa
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