STAT5 activation by human GH protects insulin-producing cells against interleukin-1β, interferon-γ and tumour necrosis factor-α-induced apoptosis independent of nitric oxide production

The proinflammatory cytokines interleukin-1β (IL-1β), interferon-γ (IFN-γ) and tumour necrosis factor-α (TNF-α) are toxic to pancreatic β-cells and are implicated in the pathogenesis of type 1 diabetes. We have previously found that GH and prolactin (PRL) stimulate both proliferation and insulin pro...

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Veröffentlicht in:	Journal of endocrinology 2005-10, Vol.187 (1), p.25-36
Hauptverfasser:	Jensen, Janne, Galsgaard, Elisabeth D, Karlsen, Allan E, Lee, Ying C, Nielsen, Jens H
Format:	Artikel
Sprache:	eng
Schlagworte:	Regular papers
Online-Zugang:	Volltext
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