Transfusion of ethylene carbodiimide–fixed donor splenocytes prolongs survival of vascularized skin allografts

Allograft rejection is a major obstacle to the widespread clinical application of vascularized composite allotransplantation. Recent studies revealed a noncytoreductive strategy to protect allografts by the transfusion of ethylene carbodiimide–fixed donor splenocytes (ECDI-SPs). To determine whether...

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Veröffentlicht in:	The Journal of surgical research 2018-01, Vol.221, p.343-352
Hauptverfasser:	Ding, Jianke, Liu, Shiqiang, Zhang, Dongliang, Song, Yajuan, Ma, Xianjie, Yi, Chenggang, Song, Baoqiang, Xiao, Bo, Su, Yingjun, Guo, Shuzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Transplantation - methods Cytokines - metabolism Ethyldimethylaminopropyl Carbodiimide Graft Rejection - immunology Graft Rejection - prevention & control Immunosuppressive Agents - administration & dosage Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Sirolimus - administration & dosage Skin Transplantation Spleen - cytology T-Lymphocytes, Regulatory Tolerance Transplantation, Homologous Vascularized composite allotransplantation
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