LNMICC Promotes Nodal Metastasis of Cervical Cancer by Reprogramming Fatty Acid Metabolism
Cancer spread to lymph nodes predicts poor survival but underlying mechanisms remain little understood. In this study, we show that overexpression of the long noncoding RNA LNMICC associates with lymph node metastasis of primary cervical cancer, where it serves as an independent high-risk factor in...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2018-02, Vol.78 (4), p.877-890 |
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| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 78 |
| creator | Shang, Chunliang Wang, Wei Liao, Yuandong Chen, Yili Liu, Tianyu Du, Qiqiao Huang, Jiaming Liang, Yanchun Liu, Junxiu Zhao, Yunhe Guo, Luyan Hu, Zheng Yao, Shuzhong |
| description | Cancer spread to lymph nodes predicts poor survival but underlying mechanisms remain little understood. In this study, we show that overexpression of the long noncoding RNA LNMICC associates with lymph node metastasis of primary cervical cancer, where it serves as an independent high-risk factor in patient survival. Functional investigations demonstrated that LNMICC promoted lymph node metastasis by reprogramming fatty acid metabolism, by recruiting the nuclear factor NPM1 to the promoter of the fatty acid binding protein FABP5. We also found that the prometastatic effects of LNMICC were directly targeted and suppressed by miR-190. Our results establish a new mechanism of lymph node metastasis and highlight LNMICC as a candidate prognostic biomarker and therapeutic target in cervical cancer.
These results establish the role of a novel long noncoding RNA in lymph node metastasis, with implications as a candidate prognostic biomarker and therapeutic target in cervical cancer.
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| doi_str_mv | 10.1158/0008-5472.CAN-17-2356 |
| format | Article |
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These results establish the role of a novel long noncoding RNA in lymph node metastasis, with implications as a candidate prognostic biomarker and therapeutic target in cervical cancer.
.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>DOI: 10.1158/0008-5472.CAN-17-2356</identifier><identifier>PMID: 29229603</identifier><language>eng</language><publisher>United States: American Association for Cancer Research, Inc</publisher><subject>Biomarkers ; Cervical cancer ; Fatty acid-binding protein ; Fatty acids ; Human papillomavirus ; Lymph nodes ; Lymphatic system ; Metabolism ; Metastases ; Metastasis ; Ribonucleic acid ; Risk factors ; Risk groups ; RNA ; Survival</subject><ispartof>Cancer research (Chicago, Ill.), 2018-02, Vol.78 (4), p.877-890</ispartof><rights>2017 American Association for Cancer Research.</rights><rights>Copyright American Association for Cancer Research, Inc. Feb 15, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-84b413d31f25288fada9ad47a7baa3d465f253bbb95f5fc4ad4aba0343df1f163</citedby><cites>FETCH-LOGICAL-c488t-84b413d31f25288fada9ad47a7baa3d465f253bbb95f5fc4ad4aba0343df1f163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3343,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29229603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shang, Chunliang</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Liao, Yuandong</creatorcontrib><creatorcontrib>Chen, Yili</creatorcontrib><creatorcontrib>Liu, Tianyu</creatorcontrib><creatorcontrib>Du, Qiqiao</creatorcontrib><creatorcontrib>Huang, Jiaming</creatorcontrib><creatorcontrib>Liang, Yanchun</creatorcontrib><creatorcontrib>Liu, Junxiu</creatorcontrib><creatorcontrib>Zhao, Yunhe</creatorcontrib><creatorcontrib>Guo, Luyan</creatorcontrib><creatorcontrib>Hu, Zheng</creatorcontrib><creatorcontrib>Yao, Shuzhong</creatorcontrib><title>LNMICC Promotes Nodal Metastasis of Cervical Cancer by Reprogramming Fatty Acid Metabolism</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Cancer spread to lymph nodes predicts poor survival but underlying mechanisms remain little understood. In this study, we show that overexpression of the long noncoding RNA LNMICC associates with lymph node metastasis of primary cervical cancer, where it serves as an independent high-risk factor in patient survival. Functional investigations demonstrated that LNMICC promoted lymph node metastasis by reprogramming fatty acid metabolism, by recruiting the nuclear factor NPM1 to the promoter of the fatty acid binding protein FABP5. We also found that the prometastatic effects of LNMICC were directly targeted and suppressed by miR-190. Our results establish a new mechanism of lymph node metastasis and highlight LNMICC as a candidate prognostic biomarker and therapeutic target in cervical cancer.
These results establish the role of a novel long noncoding RNA in lymph node metastasis, with implications as a candidate prognostic biomarker and therapeutic target in cervical cancer.
.</description><subject>Biomarkers</subject><subject>Cervical cancer</subject><subject>Fatty acid-binding protein</subject><subject>Fatty acids</subject><subject>Human papillomavirus</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Metabolism</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Ribonucleic acid</subject><subject>Risk factors</subject><subject>Risk groups</subject><subject>RNA</subject><subject>Survival</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkEFLwzAUx4Mobk4_ghLw4qUzaZI2PY7idDCniF68hKRNRkfbzKQV9u1N3dxBCDzy3u__ePwAuMZoijHj9wghHjGaxtN8topwGsWEJSdgjBnhUUopOwXjIzMCF95vwpdhxM7BKM7iOEsQGYPP5ep5kefw1dnGdtrDlS1lDZ91J314lYfWwFy776oI7Vy2hXZQ7eCb3jq7drJpqnYN57LrdnBWVOVvUtm68s0lODOy9vrqUCfgY_7wnj9Fy5fHRT5bRgXlvIs4VRSTkmATs5hzI0uZyZKmMlVSkpImLAyIUipjhpmChplUEhFKSoMNTsgE3O33hou-eu070VS-0HUtW217L3CWJkFEwgb09h-6sb1rw3UiRijJcJZgHCi2pwpnvXfaiK2rGul2AiMxyBeDWDGIFUG-wKkY5IfczWF7rxpdHlN_tskPt9p_Fw</recordid><startdate>20180215</startdate><enddate>20180215</enddate><creator>Shang, Chunliang</creator><creator>Wang, Wei</creator><creator>Liao, Yuandong</creator><creator>Chen, Yili</creator><creator>Liu, Tianyu</creator><creator>Du, Qiqiao</creator><creator>Huang, Jiaming</creator><creator>Liang, Yanchun</creator><creator>Liu, Junxiu</creator><creator>Zhao, Yunhe</creator><creator>Guo, Luyan</creator><creator>Hu, Zheng</creator><creator>Yao, Shuzhong</creator><general>American Association for Cancer Research, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20180215</creationdate><title>LNMICC Promotes Nodal Metastasis of Cervical Cancer by Reprogramming Fatty Acid Metabolism</title><author>Shang, Chunliang ; 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In this study, we show that overexpression of the long noncoding RNA LNMICC associates with lymph node metastasis of primary cervical cancer, where it serves as an independent high-risk factor in patient survival. Functional investigations demonstrated that LNMICC promoted lymph node metastasis by reprogramming fatty acid metabolism, by recruiting the nuclear factor NPM1 to the promoter of the fatty acid binding protein FABP5. We also found that the prometastatic effects of LNMICC were directly targeted and suppressed by miR-190. Our results establish a new mechanism of lymph node metastasis and highlight LNMICC as a candidate prognostic biomarker and therapeutic target in cervical cancer.
These results establish the role of a novel long noncoding RNA in lymph node metastasis, with implications as a candidate prognostic biomarker and therapeutic target in cervical cancer.
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Biomarkers Cervical cancer Fatty acid-binding protein Fatty acids Human papillomavirus Lymph nodes Lymphatic system Metabolism Metastases Metastasis Ribonucleic acid Risk factors Risk groups RNA Survival |
| title | LNMICC Promotes Nodal Metastasis of Cervical Cancer by Reprogramming Fatty Acid Metabolism |
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