Prevalence of comorbidities in COPD patients by disease severity in a German population
Chronic obstructive pulmonary disease (COPD) is commonly associated with multiple comorbidities. Our objective was to assess the prevalence of comorbidities in patients with COPD and to relate their prevalence to the severity of the disease by using a large German health care database. Based on the...
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| Veröffentlicht in: | Respiratory medicine 2017-11, Vol.132, p.132-138 |
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| creator | Greulich, Timm Weist, Benjamin J.D. Koczulla, Andreas Rembert Janciauskiene, Sabina Klemmer, Andreas Lux, Wolfram Alter, Peter Vogelmeier, Claus F. |
| description | Chronic obstructive pulmonary disease (COPD) is commonly associated with multiple comorbidities. Our objective was to assess the prevalence of comorbidities in patients with COPD and to relate their prevalence to the severity of the disease by using a large German health care database.
Based on the retrospective analysis of a two-year (2013–2014) database from the German Statutory Health Insurance system, we obtained a representative sample of 4,075,493 german insurants. This sample included 146,141 patients with COPD (age: ≥35 years). To these patients, we matched 1:1 by age and gender randomly selected non-COPD controls. We assessed the comorbidities and the use of cardiovascular drugs, and examined COPD subgroups according to lung function (ICD-10-coded FEV1) and the treatment with long-acting inhaled bronchodilators.
Compared to non-COPD, patients with COPD had a higher prevalence of hypertension, congestive heart failure, diabetes, gastroesophageal reflux disease, chronic kidney disease, osteoporosis, psychiatric disease and lung cancer, and used more cardiovascular-related drugs. However, the prevalence of comorbidities did not correlate to the severity of airflow limitation.
The results of this sizeable nationwide survey support the concept that individuals with COPD need careful evaluation regarding comorbidities. This can already be of relevance in patients with mild to moderate airflow limitation.
Comorbidities in COPD have a complex relationship with disease severity, requiring a comprehensive therapy approach.
•The severity-dependent prevalence of comorbidities in COPD can be analysed using large health care databases.•Compared to age- and gender-matched non-COPD, COPD patients have a higher prevalence of a wide variety of comorbidities.•The prevalence of comorbidities is not correlated to the severity of airflow limitation.•Individuals with COPD need careful evaluation regarding comorbidities, irrespective of the severity of airflow limitation. |
| doi_str_mv | 10.1016/j.rmed.2017.10.007 |
| format | Article |
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Based on the retrospective analysis of a two-year (2013–2014) database from the German Statutory Health Insurance system, we obtained a representative sample of 4,075,493 german insurants. This sample included 146,141 patients with COPD (age: ≥35 years). To these patients, we matched 1:1 by age and gender randomly selected non-COPD controls. We assessed the comorbidities and the use of cardiovascular drugs, and examined COPD subgroups according to lung function (ICD-10-coded FEV1) and the treatment with long-acting inhaled bronchodilators.
Compared to non-COPD, patients with COPD had a higher prevalence of hypertension, congestive heart failure, diabetes, gastroesophageal reflux disease, chronic kidney disease, osteoporosis, psychiatric disease and lung cancer, and used more cardiovascular-related drugs. However, the prevalence of comorbidities did not correlate to the severity of airflow limitation.
The results of this sizeable nationwide survey support the concept that individuals with COPD need careful evaluation regarding comorbidities. This can already be of relevance in patients with mild to moderate airflow limitation.
Comorbidities in COPD have a complex relationship with disease severity, requiring a comprehensive therapy approach.
•The severity-dependent prevalence of comorbidities in COPD can be analysed using large health care databases.•Compared to age- and gender-matched non-COPD, COPD patients have a higher prevalence of a wide variety of comorbidities.•The prevalence of comorbidities is not correlated to the severity of airflow limitation.•Individuals with COPD need careful evaluation regarding comorbidities, irrespective of the severity of airflow limitation.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2017.10.007</identifier><identifier>PMID: 29229085</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Air flow ; Biomedical materials ; Bronchodilators ; Cancer ; Cardiovascular ; Chronic obstructive pulmonary disease ; Comorbidities ; Comorbidity ; COPD ; Diabetes ; Drugs ; Health insurance ; Health risk assessment ; Hypertension ; Kidney diseases ; Lung cancer ; Musculoskeletal ; Osteoporosis ; Psychiatric disease ; Subgroups</subject><ispartof>Respiratory medicine, 2017-11, Vol.132, p.132-138</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017. Published by Elsevier Ltd.</rights><rights>Copyright Elsevier Limited Nov 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-bd4ddada2b96a5e9932b9771fc09543abdfb548e6a62e54fb147d9d54f7829983</citedby><cites>FETCH-LOGICAL-c494t-bd4ddada2b96a5e9932b9771fc09543abdfb548e6a62e54fb147d9d54f7829983</cites><orcidid>0000-0002-2368-3014 ; 0000-0001-9173-0305</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0954611117303463$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29229085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greulich, Timm</creatorcontrib><creatorcontrib>Weist, Benjamin J.D.</creatorcontrib><creatorcontrib>Koczulla, Andreas Rembert</creatorcontrib><creatorcontrib>Janciauskiene, Sabina</creatorcontrib><creatorcontrib>Klemmer, Andreas</creatorcontrib><creatorcontrib>Lux, Wolfram</creatorcontrib><creatorcontrib>Alter, Peter</creatorcontrib><creatorcontrib>Vogelmeier, Claus F.</creatorcontrib><title>Prevalence of comorbidities in COPD patients by disease severity in a German population</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Chronic obstructive pulmonary disease (COPD) is commonly associated with multiple comorbidities. Our objective was to assess the prevalence of comorbidities in patients with COPD and to relate their prevalence to the severity of the disease by using a large German health care database.
Based on the retrospective analysis of a two-year (2013–2014) database from the German Statutory Health Insurance system, we obtained a representative sample of 4,075,493 german insurants. This sample included 146,141 patients with COPD (age: ≥35 years). To these patients, we matched 1:1 by age and gender randomly selected non-COPD controls. We assessed the comorbidities and the use of cardiovascular drugs, and examined COPD subgroups according to lung function (ICD-10-coded FEV1) and the treatment with long-acting inhaled bronchodilators.
Compared to non-COPD, patients with COPD had a higher prevalence of hypertension, congestive heart failure, diabetes, gastroesophageal reflux disease, chronic kidney disease, osteoporosis, psychiatric disease and lung cancer, and used more cardiovascular-related drugs. However, the prevalence of comorbidities did not correlate to the severity of airflow limitation.
The results of this sizeable nationwide survey support the concept that individuals with COPD need careful evaluation regarding comorbidities. This can already be of relevance in patients with mild to moderate airflow limitation.
Comorbidities in COPD have a complex relationship with disease severity, requiring a comprehensive therapy approach.
•The severity-dependent prevalence of comorbidities in COPD can be analysed using large health care databases.•Compared to age- and gender-matched non-COPD, COPD patients have a higher prevalence of a wide variety of comorbidities.•The prevalence of comorbidities is not correlated to the severity of airflow limitation.•Individuals with COPD need careful evaluation regarding comorbidities, irrespective of the severity of airflow limitation.</description><subject>Air flow</subject><subject>Biomedical materials</subject><subject>Bronchodilators</subject><subject>Cancer</subject><subject>Cardiovascular</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Comorbidities</subject><subject>Comorbidity</subject><subject>COPD</subject><subject>Diabetes</subject><subject>Drugs</subject><subject>Health insurance</subject><subject>Health risk assessment</subject><subject>Hypertension</subject><subject>Kidney diseases</subject><subject>Lung cancer</subject><subject>Musculoskeletal</subject><subject>Osteoporosis</subject><subject>Psychiatric disease</subject><subject>Subgroups</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMoun78AQ8S8OKl6yRNPwJeZP0EQQ-Kx5A2U8jSNjVpF_bfm7J68eApk5lnXoaHkHMGSwYsv14vfYdmyYEVsbEEKPbIgmUpT1LIxT5ZgMxEkjPGjshxCGsAkELAITniknMJZbYgn28eN7rFvkbqGlq7zvnKGjtaDNT2dPX6dkcHHb_9GGi1pcYG1AFpwA16O25nSNNH9J3u6eCGqY2w60_JQaPbgGc_7wn5eLh_Xz0lL6-Pz6vbl6QWUoxJZYQx2mheyVxnKGUaq6JgTT3fnurKNFUmSsx1zjETTcVEYaSJVVFyKcv0hFztcgfvviYMo-psqLFtdY9uCorJIgcoU5ARvfyDrt3k-3hdpMpUiDIHFim-o2rvQvDYqMHbTvutYqBm7WqtZu1q1j73ova4dPETPVXz7Hfl13MEbnYARhcbi16F2s7SjfVYj8o4-1_-N7ohkx8</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Greulich, Timm</creator><creator>Weist, Benjamin J.D.</creator><creator>Koczulla, Andreas Rembert</creator><creator>Janciauskiene, Sabina</creator><creator>Klemmer, Andreas</creator><creator>Lux, Wolfram</creator><creator>Alter, Peter</creator><creator>Vogelmeier, Claus F.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2368-3014</orcidid><orcidid>https://orcid.org/0000-0001-9173-0305</orcidid></search><sort><creationdate>201711</creationdate><title>Prevalence of comorbidities in COPD patients by disease severity in a German population</title><author>Greulich, Timm ; Weist, Benjamin J.D. ; Koczulla, Andreas Rembert ; Janciauskiene, Sabina ; Klemmer, Andreas ; Lux, Wolfram ; Alter, Peter ; Vogelmeier, Claus F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-bd4ddada2b96a5e9932b9771fc09543abdfb548e6a62e54fb147d9d54f7829983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Air flow</topic><topic>Biomedical materials</topic><topic>Bronchodilators</topic><topic>Cancer</topic><topic>Cardiovascular</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Comorbidities</topic><topic>Comorbidity</topic><topic>COPD</topic><topic>Diabetes</topic><topic>Drugs</topic><topic>Health insurance</topic><topic>Health risk assessment</topic><topic>Hypertension</topic><topic>Kidney diseases</topic><topic>Lung cancer</topic><topic>Musculoskeletal</topic><topic>Osteoporosis</topic><topic>Psychiatric disease</topic><topic>Subgroups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greulich, Timm</creatorcontrib><creatorcontrib>Weist, Benjamin J.D.</creatorcontrib><creatorcontrib>Koczulla, Andreas Rembert</creatorcontrib><creatorcontrib>Janciauskiene, Sabina</creatorcontrib><creatorcontrib>Klemmer, Andreas</creatorcontrib><creatorcontrib>Lux, Wolfram</creatorcontrib><creatorcontrib>Alter, Peter</creatorcontrib><creatorcontrib>Vogelmeier, Claus F.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greulich, Timm</au><au>Weist, Benjamin J.D.</au><au>Koczulla, Andreas Rembert</au><au>Janciauskiene, Sabina</au><au>Klemmer, Andreas</au><au>Lux, Wolfram</au><au>Alter, Peter</au><au>Vogelmeier, Claus F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of comorbidities in COPD patients by disease severity in a German population</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2017-11</date><risdate>2017</risdate><volume>132</volume><spage>132</spage><epage>138</epage><pages>132-138</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Chronic obstructive pulmonary disease (COPD) is commonly associated with multiple comorbidities. Our objective was to assess the prevalence of comorbidities in patients with COPD and to relate their prevalence to the severity of the disease by using a large German health care database.
Based on the retrospective analysis of a two-year (2013–2014) database from the German Statutory Health Insurance system, we obtained a representative sample of 4,075,493 german insurants. This sample included 146,141 patients with COPD (age: ≥35 years). To these patients, we matched 1:1 by age and gender randomly selected non-COPD controls. We assessed the comorbidities and the use of cardiovascular drugs, and examined COPD subgroups according to lung function (ICD-10-coded FEV1) and the treatment with long-acting inhaled bronchodilators.
Compared to non-COPD, patients with COPD had a higher prevalence of hypertension, congestive heart failure, diabetes, gastroesophageal reflux disease, chronic kidney disease, osteoporosis, psychiatric disease and lung cancer, and used more cardiovascular-related drugs. However, the prevalence of comorbidities did not correlate to the severity of airflow limitation.
The results of this sizeable nationwide survey support the concept that individuals with COPD need careful evaluation regarding comorbidities. This can already be of relevance in patients with mild to moderate airflow limitation.
Comorbidities in COPD have a complex relationship with disease severity, requiring a comprehensive therapy approach.
•The severity-dependent prevalence of comorbidities in COPD can be analysed using large health care databases.•Compared to age- and gender-matched non-COPD, COPD patients have a higher prevalence of a wide variety of comorbidities.•The prevalence of comorbidities is not correlated to the severity of airflow limitation.•Individuals with COPD need careful evaluation regarding comorbidities, irrespective of the severity of airflow limitation.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29229085</pmid><doi>10.1016/j.rmed.2017.10.007</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2368-3014</orcidid><orcidid>https://orcid.org/0000-0001-9173-0305</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Air flow Biomedical materials Bronchodilators Cancer Cardiovascular Chronic obstructive pulmonary disease Comorbidities Comorbidity COPD Diabetes Drugs Health insurance Health risk assessment Hypertension Kidney diseases Lung cancer Musculoskeletal Osteoporosis Psychiatric disease Subgroups |
| title | Prevalence of comorbidities in COPD patients by disease severity in a German population |
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