Opposing Actions of Fibroblast and Cardiomyocyte Smad3 Signaling in the Infarcted Myocardium

BACKGROUND:Transforming growth factor–βs regulate a wide range of cellular responses by activating Smad-dependent and Smad-independent cascades. In the infarcted heart, Smad3 signaling is activated in both cardiomyocytes and interstitial cells. We hypothesized that cell-specific actions of Smad3 reg...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2018-02, Vol.137 (7), p.707-724
Hauptverfasser:	Kong, Ping, Shinde, Arti V, Su, Ya, Russo, Ilaria, Chen, Bijun, Saxena, Amit, Conway, Simon J, Graff, Jonathan M, Frangogiannis, Nikolaos G
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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