A priming dose protects against gold nanoparticles-induced proinflammatory cytokines mRNA expression in mice

To study the effect of priming doses of gold nanoparticles (GNPs) on proinflammatory cytokines in different organs of mice. Mice were injected with a single or two doses (priming group) of GNPs (5, 20 and 50 nm) and sacrificed after 1 or 7 days. The mRNA expressions of IL-1β, IL-6 and TNF-α were det...

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Veröffentlicht in:	Nanomedicine (London, England) England), 2018-02, Vol.13 (3), p.313-323
Hauptverfasser:	Ibrahim, Khalid Elfaki, Bakhiet, Amel Omer, Awadalla, Maaweya Elaeed, Khan, Haseeb Ahmad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioaccumulation Biocompatibility Biomedical materials Cytokines Dose-Response Relationship, Drug Gene Expression Regulation - drug effects Gold Gold - administration & dosage Gold - adverse effects gold nanoparticles IL-1β IL-6 immune activation Immune system inflammation Interleukin-1beta - genetics Interleukin-6 - genetics Kidney - drug effects Kidneys Liver Liver - drug effects Metal Nanoparticles - administration & dosage Metal Nanoparticles - adverse effects Mice Nanomaterials nanomedicine Nanoparticles Particle size Polyethylene glycol priming dose proinflammatory cytokines RNA, Messenger - genetics Spleen Spleen - drug effects TNF-α Transmission electron microscopy Tumor Necrosis Factor-alpha - genetics
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