Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma

•ΔNp63β positively regulates KLK6 and PAR2, and negatively regulates PAR1 in OSCC.•Up-regulates KLK6-PAR2 and down-regulates PAR1 induces malignant transformation.•Down-regulates KLK6-PAR2 and up-regulates PAR1 lead EMT.•KLK6 has two different roles in malignant transformation and EMT in OSCC.•KLK6...

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Veröffentlicht in:	Oral oncology 2017-12, Vol.75, p.148-157
Hauptverfasser:	Kaneko, Naoki, Kawano, Shintaro, Yasuda, Kaori, Hashiguchi, Yuma, Sakamoto, Taiki, Matsubara, Ryota, Goto, Yuichi, Jinno, Teppei, Maruse, Yasuyuki, Morioka, Masahiko, Hattori, Taichi, Tanaka, Shoichi, Tanaka, Hideaki, Kiyoshima, Tamotsu, Nakamura, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Epithelial-to-mesenchymal transition (EMT) Kallikrein-related peptidase 6 Malignant transformation Metastasis Oral cancer Oral squamous cell carcinoma (OSCC) Prognosis Protease-activated receptor ΔNp63
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