Hydrochlorothiazide and acute urinary acidification: The “voltage hypothesis” of ENaC‐dependent H+ secretion refuted

Aim The “voltage hypothesis” of H+ secretion states that urinary acidification following increased Na+ delivery to the collecting duct (CD) is ENaC dependent leading to transepithelial voltage‐dependent increase in H+ secretion. We recently showed that furosemide acidifies the urine independently of...

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Veröffentlicht in:	Acta Physiologica 2018-05, Vol.223 (1), p.e13013-n/a
Hauptverfasser:	Ayasse, N., de Bruijn, P. I. A., Berg, P., Sørensen, M. V., Leipziger, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	acid excretion Acidification Catheterization Collecting duct Diet distal convoluted tubule Diuresis epithelial Na+ channel Excretion Furosemide Hydrochlorothiazide Hydrogen Na+, Cl− cotransporter Nutrient deficiency pH effects Photometry Rodents Secretion Sodium Urinary bladder Urine Voltage Western blotting
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