Impact of peginterferon alpha-2b and ribavirin treatment on liver tissue in patients with HCV or HCV–HIV co-infection

Summary Objective To evaluate the effect of treatment with peginterferon alpha-2b and ribavirin on liver histology in patients with chronic hepatitis C (CHC) with or without HIV infection. Methods Patients received peginterferon alpha-2b (1.5 μ/kg/week during the first 4 weeks; 1.0 μ/kg/week thereaf...

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Veröffentlicht in:	The Journal of infection 2007-06, Vol.54 (6), p.609-616
Hauptverfasser:	Sarmento-Castro, Rui, Horta, Ana, Vasconcelos, Olga, Coelho, Helena, Mendez, Josefina, Tavares, Ana Paula, Seabra, João, Duarte, Manuela, Chaves, Leonor, Fortes, Olga, Recalde, Cristina, Ventura, Ângela, Pires, Nuno, Pinho, Luciana, Dias, Nancy, Carneiro, Fátima
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active Antiviral agents Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Biological and medical sciences Chronic hepatitis C Drug Therapy, Combination Female Fibrosis HCV/HIV co-infection Hepatitis C - complications Hepatitis C - drug therapy Hepatitis C virus HIV Infections - complications HIV Infections - drug therapy Human immunodeficiency virus Human viral diseases Humans Infectious Disease Infectious diseases Interferon-alpha - administration & dosage Interferon-alpha - adverse effects Interferon-alpha - pharmacology Interferon-alpha - therapeutic use Liver - drug effects Liver biopsy Liver histology Male Medical sciences Middle Aged Pegylated interferon alpha-2b Pharmacology. Drug treatments Polyethylene Glycols Recombinant Proteins Ribavirin Ribavirin - administration & dosage Ribavirin - adverse effects Ribavirin - pharmacology Ribavirin - therapeutic use Treatment Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral hepatitis
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