Enaminone Amides as Novel Orally Active GABA sub(A) Receptor Modulators

A series of enaminone esters and amides have been developed as potent allosteric modulators of gamma -aminobutyric acid sub(A) (GABA sub(A)) receptors. The compounds bind to a novel modulatory site that is independent of the benzodiazepine (BZ), isosteric GABA, and neuroactive steroid binding sites....

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Veröffentlicht in:	Journal of medicinal chemistry 2007-07, Vol.50 (14), p.3369-3379
Hauptverfasser:	Hogenkamp, D J, Johnstone, TBC, Huang, J-C, Li, W-Y, Tran, M, Whittemore, E R, Bagnera, R E, Gee, K W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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